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International Journal of Medicinal Mushrooms
IF: 1.423 5-Year IF: 1.525 SJR: 0.433 SNIP: 0.661 CiteScore™: 1.38

ISSN Print: 1521-9437
ISSN Online: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v15.i4.50
pages 373-381

MT-α-Glucan from the Fruit Body of the Maitake Medicinal Mushroom Grifola frondosa (Higher Basidiomyetes) Shows Protective Effects for Hypoglycemic Pancreatic β-Cells

Hong Lei
Department of Biological Science, School of Biology and Food Engineering, Hefei University of Technology, Hefei
Minmin Zhang
Department of Biological Science, School of Biology and Food Engineering, Hefei University of Technology, Hefei
Qin Wang
Department of Biological Science, School of Biology and Food Engineering, Hefei University of Technology, Hefei
Shuzhen Guo
Department of Biological Science, School of Biology and Food Engineering, Hefei University of Technology, Hefei
Juncheng Han
Department of Biological Science, School of Biology and Food Engineering, Hefei University of Technology, Hefei
Hanju Sun
Department of Biological Science, School of Biology and Food Engineering, Hefei University of Technology, Hefei
Wutong Wu
School of Life Science and Technology, China Pharmaceutical University, Nanjing, China

ABSTRACT

The hypoglycemic effect of an α-glucan (designated here as MT-α-glucan) from the fruit body of the Maitake medicinal mushroom, Grifola frondosa, on a murine type 2 diabetes mellitus (T2DM) model was evaluated. Body weight and levels of fasting plasma glucose, glycosylated hemoglobin, triglycerides, cholesterol, free fatty acid, nitric oxide (NO), NO synthase, inducible NO synthase, and hepatic malondialdehyde content decreased significantly when MT-α-glucan was administered to T2DM mice. The content of serum insulin, hepatic glycogen, and reduced glutathione and the activity of superoxide dismutase and glutathione peroxidase increased significantly when MT-α-glucan was administered to T2DM mice. Histopathological changes of the pancreas were ameliorated in the treatment group. These data suggest that MT-α-glucan has a hypoglycemic effect on T2DM mice, which might be related to its protective effect of pancreatic β-cells exerted by decreasing levels of factors that destroy β-cells, such as oxidative stress and NO synthesis.


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