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International Journal of Medicinal Mushrooms
IF: 1.423 5-Year IF: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Print: 1521-9437
ISSN Online: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.2017021241
pages 619-628

Antimelanomic Effects of High- and Low-Molecular Weight Bioactive Subfractions Isolated from the Mossy Maze Mushroom, Cerrena unicolor (Agaricomycetes)

Matgorzata Statkiewicz
Department of Genetics, Maria Sktodowska-Curie Memorial Cancer Centre and Institute of Oncology, Warsaw, Poland
Anna Matuszewska
Department of Biochemistry, Maria Curie-Sktodowska University, Lublin, Poland
Magdalena Jaszek
Department of Biochemistry, Maria Curie-Sktodowska University, Lublin, Poland
Grzegorz Janusz
Department of Biochemistry, Maria Curie-Sktodowska University, Lublin, Poland
Monika Osinska
Department of Biochemistry, Maria Curie-Sktodowska University, Lublin, Poland
Justyna Sulej
Department of Biochemistry, Maria Curie-Sklodowska University, Lublin, Poland
Dawid Stefaniuk
Department of Biochemistry, Institute of Biology and Biochemistry, Maria Curie-Sklodowska University, Akademicka 19, Lublin, Poland
Michat Mikula
Department of Genetics, Maria Sktodowska-Curie Memorial Cancer Centre and Institute of Oncology, Warsaw, Poland
Jerzy Ostrowski
Department of Genetics, Maria Sktodowska-Curie Memorial Cancer Centre and Institute of Oncology, Warsaw, Poland

ABSTRACT

Three bioactive fractions isolated from Cerrena unicolor cultures−crude endopolysaccharide (c-EPS), laccase, and a subfraction of low-molecular weight secondary metabolites−were used to determine potential cytotoxic effects on the mouse melanoma B16-F10 cell line (American Type Culture Collection CRL-6475). The results obtained prove that all examined fractions exhibited activity against the investigated tumor cells. In addition, an evident immunomodulatory effect of the c-EPS fraction was observed. Our results show that the levels of 2 cytokines (tumor necrosis factor-a and chemokine ligand 2) in mouse inner medullary collecting duct mIMCD-3 cells (American Type Culture Collection CRL-2123) stimulated by c-EPS were significantly higher. A lipopolysaccharide model was used at the same concentration (10 μg/mL) as a positive control.


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