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International Journal of Medicinal Mushrooms
Anti-Inflammation and Lipogenic Inhibition of Taiwanofungus salmonea Mycelium and Grifola frondosa Fruiting Body
Department of Food Science and Biotechnology, National Chung Hsing University, Taichung, Taiwan, R.O.C.; National Chung Hsing University/University of California Davis Plant and Food Biotechnology Center, National Chung Hsing University, Taichung, Taiwan, R.O.C.; Agricultural Biotechnology Center, National Chung Hsing University/University of California Davis Plant and Food Biotechnology Center, Taiwan, R.O.C.
Department of Food Science and Biotechnology, National Chung Hsing University, Taichung, Taiwan, R.O.C.
Eric Icheng Lai
Department of Biotechnology, Hungkuang University, Taichung, Taiwan, R.O.C.
Department of Food Science and Biotechnology, National Chung Hsing University, Taichung, Taiwan, Republic of China
A long-term inflammatory response can cause the development of nonalcoholic steatohepatitis (NASH), which is mainly caused by abnormal metabolism of lipids in the liver. Taiwanofungus salmonea and Grifola frondosa, which are valuable medicinal mushrooms in Taiwan and exhibit many beneficial bioactivities, are used to evaluate effects on immune regulation in Raw 264.7 cells and on NASH-related responses in Hep G2 cells. According to the results, the production of proinflammatory cytokines was effectively decreased, whereas the production of interleukin-10 was increased. Lipid accumulation and reactive oxygen species production also declined, and free glycerol was released. The expression of acetyl-CoA carboxylase, fatty acid synthase, and sterol regulatory element-binding protein 1c was decreased. These results indicate that T. salmonea and G. frondosa are capable of reducing inflammatory responses and ameliorating NASH, indicating their potential as hepatoprotective dietary supplements.
KEY WORDS: Grifola frondosa, inflammation, medicinal mushrooms, nonalcoholic steatohepatitis, Taiwanofungus salmonea
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