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International Journal of Medicinal Mushrooms
IF: 1.423 5-Year IF: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Print: 1521-9437
ISSN Online: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.2018027390
pages 887-899

Screening and Identification of Antioxidants from Ophiocordyceps xuefengensis (Ascomycetes) by Using DPPH-HPLC-DAD-Q-TOF-MS/MS

You Qin
Hunan University of Chinese Medicine, Changsha, P.R. China; Institute of Chinese Materia Medica, Hunan Academy of Chinese Medicine, Changsha, P.R. China
Lin Chen
Institute of Chinese Materia Medica, Hunan Academy of Chinese Medicine, Changsha, P.R. China; 2011 Collaboration and Innovation Center for Digital Chinese Medicine in Hunan, Changsha, P.R. China
Jian Jin
Hunan University of Chinese Medicine, Changsha, P.R. China; Institute of Chinese Materia Medica, Hunan Academy of Chinese Medicine, Changsha, P.R. China
Jianhua Huang
Hunan University of Chinese Medicine, Changsha, P.R. China
Jiayu Li
Hunan University of Chinese Medicine, Changsha, P.R. China; Institute of Chinese Materia Medica, Hunan Academy of Chinese Medicine, Changsha, P.R. China
Qingyijun Zhou
Hunan University of Chinese Medicine, Changsha, P.R. China; Institute of Chinese Materia Medica, Hunan Academy of Chinese Medicine, Changsha, P.R. China
Rongrong Zhou
Changchun University of Chinese Medicine, Changchun, P.R. China
Shui-han Zhang
Institute of Chinese Materia Medica, Hunan Academy of Chinese Medicine, Changsha, P.R. China; 2011 Collaboration and Innovation Center for Digital Chinese Medicine in Hunan, Changsha, P.R. China

ABSTRACT

Ophiocordyceps xuefengensis has recently been identified as a sister taxon of O. sinensis and has long been recognized as a folk tonic, food, or invigorant in South China. This study had 3 aims: First, we analyzed the antioxidant activities of 3 kinds of caterpillar fungi; the antioxidative ability of the various caterpillar fungi were in the order of O. xuefengensis > Cordyceps militaris > O. sinensis. Second, we further identified the antioxidant compounds in O. xuefengensis by using various methods: multiwavelength DPPH high-performance liquid chromatography with diode array detection and quadrupole time-of-flight mass spectrometry. In this way, we found and identified 30 compounds that possessed potential antioxidant activity. Among these compounds, 23 compounds were determined to be composed of nucleosides, nucleotides, and amino acids. To our knowledge, several compounds in O. xuefengensis are reported here for the first time. Third, we compared the antioxidant markers in 3 caterpillar fungi. Results showed that the caterpillar fungi share some common antioxidants, while each also had its own characteristic compounds that correspond to its antioxidant capacity. This is to our knowledge the first report of the screening and identification of antioxidants in O. xuefengensis, and these results might provide beneficial contributions to understandings of O. xuefengensis on the basis of its chemical compounds and antioxidant activity.


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