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International Journal of Medicinal Mushrooms
IF: 1.423 5-Year IF: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Print: 1521-9437
ISSN Online: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.v18.i8.60
pages 699-711

Metabolomic Investigation of Rat Serum Following Oral Administration of the Willow Bracket Medicinal Mushroom, Phellinus igniarius (Agaricomycetes), by UPLC-HDMS

Yu Dong
Department of Medicine, Zhejiang Academy of Traditional Chinese Medicine, Hangzhou, China; Zhejiang Chinese Medical University, Hangzhou, China
Ying He
Zhejiang Chinese Medical University, Hangzhou, China
Zhongming Yu
Department of Medicine, Zhejiang Academy of Traditional Chinese Medicine, Hangzhou, China
Yang Zhang
Department of Medicine, Zhejiang Academy of Traditional Chinese Medicine, Hangzhou, China
Nani Wang
Department of Medicine, Zhejiang Academy of Traditional Chinese Medicine, Hangzhou, China
Dan Shou
Department of Medicine, Zhejiang Academy of Traditional Chinese Medicine, Hangzhou, China; Department of Chemistry, Xixi Campus, Zhejiang University, Hangzhou, China
Changyu Li
Zhejiang Chinese Medical University, Hangzhou, China

ABSTRACT

The medicinal willow bracket mushroom, Phellinus igniarius, is a species that has been reported to possess antibacterial, antioxidative, antitumor, antidiabetic, and antihyperlipidemia activities. The aim of this study was to elucidate the changes in endogenous metabolites after oral administration of a decoction of Ph. Igniarius. Ultraperformance liquid chromatography (UPLC)/electrospray ionization synapt high-definition mass spectrometry (ESI-HDMS) combined with pattern recognition approaches, including principal component analysis and orthogonal partial least squares discriminant analysis, were integrated to discover differentiating metabolites. The current metabolomics approach identified 16 ions (5 in the negative mode, 11 in the positive mode) as "differentiating metabolites". The results illustrated that Ph. Igniarius is likely to increase the biosynthesis and secretion of bile acids that provide hypolipidemic activity and showed that robust UPLC/ESI-HDMS techniques are promising for profiling analysis of medicinal mushroom metabolites.


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