Published 12 issues per year
ISSN Print: 1521-9437
ISSN Online: 1940-4344
IF:
1.2
5-Year IF:
1.4
Immediacy Index:
0.3
Eigenfactor:
0.00066
JCI:
0.34
SJR:
0.274
SNIP:
0.41
CiteScore™::
2.8
H-Index:
37
Indexed in
Antiviral Activity of a Cloned Peptide RC28 Isolated from the Higher Basidiomycetes Mushroom Rozites caperata in a Mouse Model of HSV-1 Keratitis
Get access
ABSTRACT
An Escherichia coli−expressed peptide with a molecular weight of 28.26, derived from the complementary DNA of antiviral protein RC28 isolated from the mushroom Rozites caperata (=Cortinarius caperatus), demonstrated potent antiviral activity against herpes simplex virus-1 in Vero cells and in a herpes simplex virus-1 mouse keratitis model. Plaque assays in Vero cells showed that the peptide reduced viral yields by at least 1.2 logs; in the animal model the cloned peptide delayed the occurrence of stromal keratitis and alleviated the severity of the disease. We believe this is the first report of a cloned mushroom peptide with antiviral activity for the prevention and treatment of a viral disease.
-
Pradeep Prabin, Manju Vidya, Ahsan Mohammad Feraz, Antiviral Potency of Mushroom Constituents, in Medicinal Mushrooms, 2019. Crossref
-
Seo Dong Joo, Choi Changsun, Antiviral Bioactive Compounds of Mushrooms and Their Antiviral Mechanisms: A Review, Viruses, 13, 2, 2021. Crossref
-
Painuli Sakshi, Semwal Prabhakar, Egbuna Chukwuebuka, Mushroom: Nutraceutical, Mineral, Proximate Constituents and Bioactive Component, in Functional Foods and Nutraceuticals, 2020. Crossref