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International Journal of Medicinal Mushrooms

Published 12 issues per year

ISSN Print: 1521-9437

ISSN Online: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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A Polysaccharide Isolated from Mycelia of the Lion’s Mane Medicinal Mushroom Hericium erinaceus (Agaricomycetes) Induced Apoptosis in Precancerous Human Gastric Cells

Volume 19, Issue 12, 2017, pp. 1053-1060
DOI: 10.1615/IntJMedMushrooms.2017024975
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ABSTRACT

Hericium erinaceus is typically used in traditional Chinese medicine for mucosal protection, healing of gastric ulcers, and treatment of gastritis. We purified from the cultured mycelia of H. erinaceus a polysaccharide with anti–gastric ulcer and antigastritis activity, but its effects on gastric malignancy have not been elucidated. We examined the differential effects of this purified polysaccharide, named EP-1, on the human gastric (GES-1) cell line and a precancerous cell line (MC) that was transformed from GES-1 using N-methyl-N'-nitro-N-nitrosoguanidine. We observed that the polysaccharide potently induced cell apoptosis and cell cycle arrest at the G0/G1 phase in the MC cell line but did not have any effect on the GES-1 cell line at the same doses. Further mechanistic studies revealed that the polysaccharide exerted its activity through an apoptosis-associated pathway by modulating the expression of Bax, Bcl-2, and caspase-3. Differential effects of the polysaccharide on the GES-1 and MC cell lines indicate that the polysaccharide was effective in preventing gastric cancer progression.

CITED BY
  1. Aras Aliye, Khalid Sumbul, Jabeen Saima, Farooqi Ammad Ahmad, Xu Baojun, Regulation of cancer cell signaling pathways by mushrooms and their bioactive molecules: Overview of the journey from benchtop to clinical trials, Food and Chemical Toxicology, 119, 2018. Crossref

  2. Chen Zhixia (Grace), Bishop Karen Suzanne, Tanambell Hartono, Buchanan Peter, Quek Siew Young, Assessment of In Vitro Bioactivities of Polysaccharides Isolated from Hericium Novae-Zealandiae, Antioxidants, 8, 7, 2019. Crossref

  3. Yang Liangjun, Li Jiali, Hu Zhipeng, Fan Xiangzhen, Cai Tiantian, Hengli Zhou , Pan Huafeng, A Systematic Review of the Mechanisms Underlying Treatment of Gastric Precancerous Lesions by Traditional Chinese Medicine, Evidence-Based Complementary and Alternative Medicine, 2020, 2020. Crossref

  4. Winder Mateusz, Bulska-Będkowska Weronika, Chudek Jerzy, The use of Hericium erinaceus and Trametes versicolor extracts in supportive treatment in oncology, Acta Pharmaceutica, 71, 1, 2021. Crossref

  5. Chen Liping, He Chunrong, Zhou Min, Long Jiaying, Li Ling, Research Progress on the Mechanisms of Polysaccharides against Gastric Cancer, Molecules, 27, 18, 2022. Crossref

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