Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
International Journal of Medicinal Mushrooms
IF: 1.423 5-Year IF: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Print: 1521-9437
ISSN Online: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v12.i3.60
pages 273-278

Antinociceptive Activity of Agaricoglycerides Extracted from Mycelium of Ling Zhi or Reishi Medicinal Mushroom, Ganoderma lucidum (W. Curt.: Fr.) P. Karst. (Aphyllophoromycetideae)

Chunchao Han
School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, People's Republic of China


The antinociceptive activity of agaricoglycerides extracted from mycelium of Ling Zhi or Reishi medicinal mushroom, Ganoderma lucidum (AMG) was studied. The writhing test, formalin test, and hot-plate test, as well as the in vitro neurolysin inhibition assay, were respectively used to evaluate the antinociceptive activity of agaricoglycerides. The extracted agaricoglycerides inhibited acetic acid-induced abdominal constrictions in mice in a dose-dependent manner (P < .05). Both phases of response to the formalin test were also significantly inhibited (P < .05). The results from the hot-plate test showed that the extract significantly (P < .05) inhibited the reaction time to thermal stimuli at 30, 60, and 90 min after application. In the neurolysin inhibition assay, AMG showed strong activities against neurolysin (IC50 = 100 nM). Our results indicate that if the same effects in humans or higher animals are shown, AMG may have potential applications as a component of analgesic food/ feed and possibly even as a medicine.

Articles with similar content:

Effects of a Hot-Water Extract of Trametes versicolor (L.: Fr.) Lloyd (Aphyllophoromycetideae) on the Recovery of Rat Liver Function
International Journal of Medicinal Mushrooms, Vol.2, 2000, issue 1
Ha Won Kim, Byong Kak Kim, So Young Kim, Mi Ja Shim, Jin Won Hyun, Sang Eun Park
Evaluation of Antianxiety Potential of Four Ganoderma (Agaricomycetes) Species from India in Mice
International Journal of Medicinal Mushrooms, Vol.18, 2016, issue 11
Richa Shri, Gurpaul Singh Dhingra, Ranjeet Singh
Scientific Validation of the Chinese Caterpillar Medicinal Mushroom, Ophiocordyceps sinensis (Ascomycetes) from India: Immunomodulatory and Antioxidant Activity
International Journal of Medicinal Mushrooms, Vol.16, 2014, issue 6
Kshipra Misra, Richa Rathor, Prem Singh Negi, Amitabh, Vandana Kirar, Praveen Vats, Kamla P. Mishra, Mamta Pal
Renoprotective Effects of Shout Camphor Medicinal Mushroom (Taiwanofungus camphorates, Basidiomycetes) Mycelia on Several Media in Mice with Chronic Kidney Disease
International Journal of Medicinal Mushrooms, Vol.18, 2016, issue 12
Shu-Chi Wang, Alexandru Mihai Grumezescu, Yu-Mei Lin, Hsin-Yi Su, Cing-Yan Jhang, Chih-Hui Yang, Keng-Shiang Huang, Jiun-Hua Chou, Ruo-Yun Chung, Wei-Ting Wang
In Vitro Protective Effects of Terminalia arjuna Bark Extracts Against the 4-Nitroquinoline-N-Oxide Genotoxicity
Journal of Environmental Pathology, Toxicology and Oncology, Vol.21, 2002, issue 1
Milena Villarini, Giuseppina Scassellati-Sforzolini, Cristina Fatigoni, Subodh Kumar, Massimiliano Marcarelli, Satwinderjeet Kaur, Massimo Moretti, Iqbal S. Grover, Rossana Pasquini