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International Journal of Medicinal Mushrooms
IF: 1.423 5-Year IF: 1.525 SJR: 0.433 SNIP: 0.661 CiteScore™: 1.38

ISSN Print: 1521-9437
ISSN Online: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v12.i3.60
pages 273-278

Antinociceptive Activity of Agaricoglycerides Extracted from Mycelium of Ling Zhi or Reishi Medicinal Mushroom, Ganoderma lucidum (W. Curt.: Fr.) P. Karst. (Aphyllophoromycetideae)

Chunchao Han
School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, People's Republic of China


The antinociceptive activity of agaricoglycerides extracted from mycelium of Ling Zhi or Reishi medicinal mushroom, Ganoderma lucidum (AMG) was studied. The writhing test, formalin test, and hot-plate test, as well as the in vitro neurolysin inhibition assay, were respectively used to evaluate the antinociceptive activity of agaricoglycerides. The extracted agaricoglycerides inhibited acetic acid-induced abdominal constrictions in mice in a dose-dependent manner (P < .05). Both phases of response to the formalin test were also significantly inhibited (P < .05). The results from the hot-plate test showed that the extract significantly (P < .05) inhibited the reaction time to thermal stimuli at 30, 60, and 90 min after application. In the neurolysin inhibition assay, AMG showed strong activities against neurolysin (IC50 = 100 nM). Our results indicate that if the same effects in humans or higher animals are shown, AMG may have potential applications as a component of analgesic food/ feed and possibly even as a medicine.

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