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International Journal of Medicinal Mushrooms
IF: 1.423 5-Year IF: 1.525 SJR: 0.433 SNIP: 0.661 CiteScore™: 1.38

ISSN Print: 1521-9437
ISSN Online: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v12.i3.20
pages 235-244

Antihyperglycemic and Antilipidperoxidative Effects of Polysaccharides Extracted from Medicinal Mushroom Chaga, Inonotus obliquus (Pers.: Fr.) Pilát (Aphyllophoromycetideae) on Alloxan-Diabetes Mice

Xin Xu
Wuxi No. 2 People's Hospital, Wuxi 214002, People's Republic of China
Chong Pang
Wuxi No. 2 People's Hospital, Wuxi, China
Chengjian Yang
Wuxi No. 2 People's Hospital, Wuxi 214002, People's Republic of China
Yitong Zheng
Wuxi No. 2 People's Hospital, Wuxi, China
Hongyu Xu
School of Pharmaceutical Science, Jiangnan University, Wuxi, China
Zhenming Lu
School of Pharmaceutical Science, Jiangnan University, Wuxi, China
Zheng-Hong Xu
School of Pharmaceutical Science, Jiangnan University, Wuxi, China; Wuxi No. 2 People's Hospital, WuXi, China

ABSTRACT

The optimum conditions for the extraction of crude polysaccharides from dry matter of culture broth (DMCB) of Inonotus obliquus were determined by using response surface methodology (RSM). In alloxan-induced diabetic mice, treatment with polysaccharide extract from DMCB of I. obliquus (150 and 300 mg/kg body weight for 21 days) showed a significant decrease in blood glucose level, with percentage reductions of 16.64% and 20.09% at the 7th day, and 29.71% and 36.36% at the 21st day, respectively. Furthermore, polysaccharide treatment significantly decreased serum contents of free fatty acid, total cholesterol, triglyceride, and low-density lipoprotein cholesterol, whereas it effectively increased high-density lipoprotein cholesterol, insulin levels, and hepatic glycogen contents in the liver of diabetic mice. In addition, the polysaccharides significantly increased catalase, superoxide dismutase, and glutathione peroxidase activities, whereas they decreased the maleic dialdehyde level in diabetic mice. A histological morphology examination showed that the polysaccharides restored the damage of pancreatic tissues in mice with diabetes mellitus. The results revealed that the I. obliquus polysaccharides possessed antihyperglycemic, antilipidperoxidative, and antioxidant effects in alloxan-induced diabetic mice.


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