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International Journal of Medicinal Mushrooms

Published 12 issues per year

ISSN Print: 1521-9437

ISSN Online: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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Antihyperglycemic and Antilipidperoxidative Effects of Polysaccharides Extracted from Medicinal Mushroom Chaga, Inonotus obliquus (Pers.: Fr.) Pilát (Aphyllophoromycetideae) on Alloxan-Diabetes Mice

Volume 12, Issue 3, 2010, pp. 235-244
DOI: 10.1615/IntJMedMushr.v12.i3.20
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ABSTRACT

The optimum conditions for the extraction of crude polysaccharides from dry matter of culture broth (DMCB) of Inonotus obliquus were determined by using response surface methodology (RSM). In alloxan-induced diabetic mice, treatment with polysaccharide extract from DMCB of I. obliquus (150 and 300 mg/kg body weight for 21 days) showed a significant decrease in blood glucose level, with percentage reductions of 16.64% and 20.09% at the 7th day, and 29.71% and 36.36% at the 21st day, respectively. Furthermore, polysaccharide treatment significantly decreased serum contents of free fatty acid, total cholesterol, triglyceride, and low-density lipoprotein cholesterol, whereas it effectively increased high-density lipoprotein cholesterol, insulin levels, and hepatic glycogen contents in the liver of diabetic mice. In addition, the polysaccharides significantly increased catalase, superoxide dismutase, and glutathione peroxidase activities, whereas they decreased the maleic dialdehyde level in diabetic mice. A histological morphology examination showed that the polysaccharides restored the damage of pancreatic tissues in mice with diabetes mellitus. The results revealed that the I. obliquus polysaccharides possessed antihyperglycemic, antilipidperoxidative, and antioxidant effects in alloxan-induced diabetic mice.

CITED BY
  1. De Silva Dilani D., Rapior Sylvie, Hyde Kevin D., Bahkali Ali H., Medicinal mushrooms in prevention and control of diabetes mellitus, Fungal Diversity, 56, 1, 2012. Crossref

  2. Fu Jianfang, Fu Jufang, Yuan Jun, Zhang Nanyan, Gao Bin, Fu Guoqiang, Tu Yanyang, Zhang Yongsheng, Anti-diabetic activities of Acanthopanax senticosus polysaccharide (ASP) in combination with metformin, International Journal of Biological Macromolecules, 50, 3, 2012. Crossref

  3. Pan Li-Hua, Li Xiu-Fang, Wang Mei-Na, Zha Xue-Qiang, Yang Xue-Fei, Liu Zhong-Jian, Luo Yi-Bo, Luo Jian-Ping, Comparison of hypoglycemic and antioxidative effects of polysaccharides from four different Dendrobium species, International Journal of Biological Macromolecules, 64, 2014. Crossref

  4. Ying You-Min, Zhang Lin-Yan, Zhang Xia, Bai Hai-Bo, Liang Dong-E, Ma Lie-Feng, Shan Wei-Guang, Zhan Zha-Jun, Terpenoids with alpha-glucosidase inhibitory activity from the submerged culture of Inonotus obliquus, Phytochemistry, 108, 2014. Crossref

  5. Wang Lian-Xia, Lu Zhen-Ming, Geng Yan, Zhang Xiao-Mei, Xu Guo-Hua, Shi Jin-Song, Xu Zheng-Hong, Stimulated production of steroids in Inonotus obliquus by host factors from birch, Journal of Bioscience and Bioengineering, 118, 6, 2014. Crossref

  6. Chaturvedi D., Dwivedi P.K., Recent Developments on the Antidiabetic Sesquiterpene Lactones and Their Semisynthetic Analogues, in Discovery and Development of Antidiabetic Agents from Natural Products, 2017. Crossref

  7. Zhang Jiao-Jiao, Li Ya, Zhou Tong, Xu Dong-Ping, Zhang Pei, Li Sha, Li Hua-Bin, Bioactivities and Health Benefits of Mushrooms Mainly from China, Molecules, 21, 7, 2016. Crossref

  8. Wang Jia, Wang Cong, Li Shuqin, Li Weiwei, Yuan Guoqi, Pan Yuxiang, Chen Haixia, Anti-diabetic effects of Inonotus obliquus polysaccharides in streptozotocin-induced type 2 diabetic mice and potential mechanism via PI3K-Akt signal pathway, Biomedicine & Pharmacotherapy, 95, 2017. Crossref

  9. Sheng Yao, Zhao Changhui, Zheng Shujuan, Mei Xiaohong, Huang Kunlun, Wang Guoyi, He Xiaoyun, Anti‐obesity and hypolipidemic effect of water extract from Pleurotus citrinopileatus in C57 BL /6J mice , Food Science & Nutrition, 7, 4, 2019. Crossref

  10. Prabhakar Pranav Kumar, Hypoglycemic potential of mushroom and their metabolites, in New and Future Developments in Microbial Biotechnology and Bioengineering, 2020. Crossref

  11. Lu Yangpeng, Jia Yanan, Xue Zihan, Li Nannan, Liu Junyu, Chen Haixia, Recent Developments in Inonotus obliquus (Chaga mushroom) Polysaccharides: Isolation, Structural Characteristics, Biological Activities and Application, Polymers, 13, 9, 2021. Crossref

  12. Zhang Zhe, Liang Xi, Tong Lingjun, Lv Youyou, Yi Huaxi, Gong Pimin, Tian Xiaoying, Cui Qingyu, Liu Tongjie, Zhang Lanwei, Effect of Inonotus obliquus (Fr.) Pilat extract on the regulation of glycolipid metabolism via PI3K/Akt and AMPK/ACC pathways in mice, Journal of Ethnopharmacology, 273, 2021. Crossref

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