Published 12 issues per year
ISSN Print: 1521-9437
ISSN Online: 1940-4344
Indexed in
Testing of Biologically Active Compounds in Stropharia rugosoannulata Far I. ex Murr. (Agaricales s.l., Basidiomycetes)
ABSTRACT
Effects of water and ethanol extracts of raw fruiting bodies of the cultivated edible mushroom Stropharia rugosoannulata Farl. ex Murr., (Agaricales s.l., Basidiomycetes) (commercial strain "Gelb" with yellow caps) on spike activity of identified neurons of mollusk Helix lucorum L. were studied. Distinct characteristics of the H. lucorum nervous system permit interpreting the results of the effect of biologically active compounds (BACs) on the same identified neurons of different individuals. The general effect of water extracts consisted in a stable increase of impulse activity that was preserved during the entire period of extract application. The ethanol extracts caused a threefold increase of frequency with two phases of stimulation activity. The data obtained make it possible to regard the S. rugosoannulata BAC activity as nontoxic and decreasing during a thermal treatment. Further investigations of the chemical nature and capacity of S. rugosoannulata BAC to penetrate through the hematoencephalic barrier are extremely important. This problem is of great significance for neuropharmacology and for possible medicinal application of this valuable edible mushroom.