Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
International Journal of Medicinal Mushrooms
IF: 1.423 5-Year IF: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Print: 1521-9437
ISSN Online: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.v19.i3.80
pages 257-265

Preclinical Assessment of Cardiovascular Alterations Induced by Birch Polypore Mushroom, Piptoporus betulinus (Agaricomycetes)

James Oluwagbamigbe Fajemiroye
Faculty of Pharmacy, Federal University of Goias, Goiania, GO, Brazil; Department of Pharmacological Sciences, Federal University of Goias, Campus Samambaia, Goiania, GO, Brazil
Aline A. Mourão
Center for Neuroscience and Cardiovascular Research, Biological Sciences Institute, Federal University of Goias, Campus Samambaia, Goiania, GO, Brazil
Stefanne Madalena Marques
Center for Neuroscience and Cardiovascular Research, Biological Sciences Institute, Federal University of Goias, Campus Samambaia, Goiania, GO, Brazil
Lanussy Porfiro de Oliveira
Faculty of Pharmacy, Federal University of Goias, Goiania, GO, Brazil
Jeronimo Raimundo de Oliveira Neto
Department of Pharmacological Sciences, Federal University of Goias, Campus Samambaia, Goiania, GO, Brazil
Abimbola Christanah Elusiyan
Drug Research and Production Unit, Faculty of Pharmacy, Obafemi Awolowo University, Ile Ife, Osun State, Nigeria
Gustavo Rodrigues Pedrino
Center for Neuroscience and Cardiovascular Research, Biological Sciences Institute, Federal University of Goias, Campus Samambaia, Goiania, GO, Brazil
Elson Alves Costa
Faculty of Pharmacy, Federal University of Goias, Goiania, GO, Brazil
Luiz Carlos da Cunha
Faculty of Pharmacy, Federal University of Goias, Goiania, GO, Brazil
Jordan K. Zjawiony
Division of Pharmacognosy, Department of BioMolecular Sciences, University of Mississippi School of Pharmacy, University, Mississippi

ABSTRACT

Piptoporus betulinus has been used in folk medicine for millennia. However, no data currently exist regarding its potential cardiovascular activity. In this work, the crude ethanolic extract and fractions (hexane, ethyl acetate, and water) with increased polarity from the partitioning process, as well as stigmasterol (the major metabolite isolated from P. betulinus), were administered orally at different doses to normotensive male Wistar rats an hour before recording mean arterial pressure, heart rate, renal blood flow, renal vascular conductance, arterial blood flow, and arterial vascular conductance. The acute oral administration of crude ethanolic extract and all fractions did not alter mean arterial pressure when compared with the control group, which received a vehicle. In addition, subchronic (14 days) oral administration of crude ethanolic extract, fractions, and stigmasterol did not alter cardiovascular parameters. In conclusion, our findings demonstrate that oral administration of organic extracts of P. betulinus did not induce cardiovascular alterations.


Articles with similar content:

Hypoglycemic and Hypolipidemic Effects of the Cracked-Cap Medicinal Mushroom Phellinus rimosus (Higher Basidiomycetes) in Streptozotocin-Induced Diabetic Rats
International Journal of Medicinal Mushrooms, Vol.17, 2015, issue 6
Thekkuttuparambil Ananthanarayanan Ajith, Kainoor K. Janardhanan, Kuttikkadan A. Rony
Antioxidant Effects of Medicinal Mushrooms Agaricus brasiliensis and Ganoderma lucidum (Higher Basidiomycetes): Evidence from Animal Studies
International Journal of Medicinal Mushrooms, Vol.17, 2015, issue 10
Solomon P. Wasser, Nataliya O. Sybirna, Borys Yurkiv, Eviatar D. Nevo
Antioxidant and Antitumor Activities of Cultured Mycelium of Culinary-Medicinal Paddy Straw Mushroom Volvariella volvacea (Bull.: Fr.) Singer (Agaricomycetideae)
International Journal of Medicinal Mushrooms, Vol.10, 2008, issue 2
Kainoor K. Janardhanan, Kuttikkadan A. Rony, Thozhuthumparambil P. Smina, Naraycinci P. Sudheesh, John Mathew
Antimutagenic Activity of Methanolic Extract of Culinary-Medicinal Oyster mushroom, Pleurotus ostreatus (Jacq.:Fr.) Kumm. (strain florida Eger nom. nud.) and Its Protective Effect Against Benzo [a] Pyrene-Induced Hepatic Damages
International Journal of Medicinal Mushrooms, Vol.6, 2004, issue 2
Thekkuttuparambil Ananthanarayanan Ajith, Kainoor K. Janardhanan, Nayana Jose, Bhaskaran Lakshmi
Antioxidant and Hepatoprotective Effects of Crataegus songarica Methanol Extract
Journal of Environmental Pathology, Toxicology and Oncology, Vol.33, 2014, issue 2
Akbar Masood, Ovais Zargar, Mohammad Afzal Zargar, Showkat Ahmad Ganie, Shajrul Amin, Parvaiz Ahmad Dar, Shayaq Ul Abeer, Rabia Hamid, Tanveer Ali Dar, Bilal Zargar