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International Journal of Medicinal Mushrooms
IF: 1.423 5-Year IF: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Print: 1521-9437
ISSN Online: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.v17.i2.60
pages 151-160

Immunomodulatory Activities on RAW 264.7 Macrophages of a Polysaccharide from Veiled Lady Mushroom, Dictyophora indusiata (Higher Basidiomycetes)

Haitian Fu
School of Pharmaceutics Science, Jiangnan University, Wuxi 214122, People's Republic of China
Chao Deng
Wuxi Medical School, Jiangnan University, Wuxi 214122, People's Republic of China
Liping Teng
Wuxi Medical School, Jiangnan University, Wuxi 214122, People's Republic of China
Li Yu
School of Pharmaceutics Science, Jiangnan University, Wuxi 214122, People's Republic of China
Tong Su
Wuxi No. 2 People's Hospital, Wuxi 214002, People's Republic of China
Xin Xu
Wuxi No. 2 People's Hospital, Wuxi 214002, People's Republic of China
Jinghua Chen
School of Pharmaceutics Science, Jiangnan University, Wuxi 214122, People's Republic of China
Chengjian Yang
Wuxi No. 2 People's Hospital, Wuxi 214002, People's Republic of China

ABSTRACT

A water-soluble polysaccharide named DI was extracted from the fruiting bodies of gastroid mushroom Dictyophora indusiata with boiling water. The chemical and physical characteristics of DI were investigated by a combination of chemical and instrumental analysis methods. The immunomodulatory activities on RAW 264.7 macrophage of DI in vitro were also studied. The results showed that DI is a β-(1→3)-glucan with side branches of β-(1→6)-glucosyl units, and it has triple-helical structure. DI has no toxic effect on cells, but can promote macrophage multiplication. DI significantly affects the immune function by promoting the production of nitric oxide and cytokines, such as tumor necrosis factor-α, interleukin-1, -6, and -12, showing an obvious dose-effect relationship. This work extends the application scope of the polysaccharide from D. indusiata in the biomedical field.


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