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International Journal of Medicinal Mushrooms

Published 12 issues per year

ISSN Print: 1521-9437

ISSN Online: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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Medicinal Value of Turkey Tail Fungus Trametes versicolor (L.:Fr.) Pilat (Aphyllophoromycetideae)

Volume 7, Issue 3, 2005, pp. 346-347
DOI: 10.1615/IntJMedMushrooms.v7.i3.100
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ABSTRACT

Trametes versicolor, formerly Coriolus versicolor, is a common fan-shaped polypore fungus of dead and dying trees throughout the world, which is an important part of forest ecology as a primary decomposer of hardwood. The fungus is characterized among the white-rot basidiomycetes. T. versicolor produces a laccase used to detoxify xenobiotics such as polychlorinated biphenyls, dyes, and a variety of synthetic polymers and as a pulp biobleach for making paper.
Turkey tail is arguably the best-researched medicinal mushroom, with a number of controlled clinical trials demonstrating increased long-term survivability in patients with gastrointestinal cancers, and to a lesser degree other cancers, with oral application of concentrated extracts of the fruit bodies and mycelium, particularly PSK and PSP. These commercially produced extracts are often prescribed along with chemotherapy for treating cancer in Japan and are paid for by national health care.
PSK and PSP have demonstrated a wide range of immunological effects in vitro and in vivo, particularly reticuloendothelial system activation, cytokine modulation (IFN-γ production, IL-2 production), enhancement of dendritic cell viability, T-cell maturation, natural killer cell activity, antibody production, and antitumor and anticancer effects. The extracts can inhibit carcinogenesis and tumor cell growth by activating cancer cell apoptosis.
Current clinical use in North America, Europe, and Asia of products containing turkey tail extracts and their use as health food supplements has rapidly increased in the last few years, with many types of products becoming available. They are often recommended as supportive treatment for their supposed immunorestorative effects in patients with chronic conditions such as various cancers and viral syndromes such as hepatitis C and for its hepatoprotective effects.
Since 1990, a number of controlled clinical trials have been performed in Japan with PSK as a supportive treatment in hospitals and clinics for treating patients with a variety of cancers, particularly colorectal and stomach cancer, but also breast and lung cancers. PSK is given orally, always along with various chemotherapeutic regimes. In several of these multicentric trials (n = 103−462), the 15-year survival rate was increased by 10−15%, and side effects of chemotherapy, such as nausea and anorexia, were reduced when PSK was given along with chemotherapy. Improvements in immune functions such as blood leukocyte and neutrophil counts, serum IgG and IgM, and body-mass index were seen in patients receiving turkey tail extracts with chemotherapy vs. chemotherapy alone.
Fundamental questions about the effectiveness of turkey tail extracts for life prolongation and mitigation of side effects from chemo- and radiotherapy in cancer patients, as well as its effectiveness as an immunorestorative and antiviral treatment in patients with chronic viral syndromes, remain to be fully answered. The dose, the solvents used for extraction, the source of starting material, the question of whether fruiting bodies or more easily obtained mycelium cultures should be used, and the duration of treatment have only been partially clarified. Because ubiquitous cell wall components of fungi (including yeasts) and bacteria, (13)-β-D-glucans, are thought to be among the most important active constituents, a careful review of the large body of existing literature on the cellular mechanisms of effects on the immune system with oral exposure of these compounds has to be carefully considered.

CITED BY
  1. Dumlupinar Berrak, Immunomodulatory and antiinflammatory activities of terrestrial fungal polysaccharides: A review, in Bioactive Natural Products, 69, 2021. Crossref

  2. Badalyan Susanna M., Rapior Sylvie, The Neurotrophic and Neuroprotective Potential of Macrofungi, in Medicinal Herbs and Fungi, 2021. Crossref

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