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International Journal of Medicinal Mushrooms
IF: 1.423 5-Year IF: 1.525 SJR: 0.431 SNIP: 0.716 CiteScore™: 2.6

ISSN Print: 1521-9437
ISSN Online: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v12.i4.70
pages 401-406

Suppressing the Formation of Osteoclasts Using Bioactive Components of the Edible Mushroom Leccinum extremiorientale (L Vass.) Singer (Agaricomycetideae)

Jae-Hoon Choi
Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, Shizuoka, Japan
Nobuhiko Ozawa
Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, Shizuoka, Japan
Kikuko Masuda
Graduate School of Marine Science and Technology, Tokyo University of Marine Science and Technology, 4-5-7, Konan, Minato-ku, Tokyo, 108-8477, Japan
Tomoyuki Koyama
Graduate School of Marine Science and Technology, Tokyo University of Marine Science and Technology, 4-5-7, Konan, Minato-ku, Tokyo, 108-8477, Japan
Kazunaga Yazawa
Graduate School of Marine Science and Technology, Tokyo University of Marine Science and Technology, 4-5-7, Konan, Minato-ku, Tokyo, 108-8477, Japan
Hirokazu Kawagishi
Research Institute of Green Science and Technology, Shizuoka University, Shizuoka, Japan; Graduate School of Agriculture, Shizuoka University, Shizuoka, Japan; and Graduate School of Science and Technology, Shizuoka University, Japan

ABSTRACT

Osteoporosis is a serious health problem for postmenopausal women and the elderly. We have focused our research on the bioactive substances from mushrooms to help cure osteoporosis by suppressing the formation of osteoclasts. In this study, two sterols were isolated from an edible mushroom Leccinum extremiorientale. The structures of 1 and 2 were identified by spectroscopic analysis. Compounds 1 and 2 showed the ability to suppress the formation of osteoclasts. This is the first report of the isolation of the compounds from the genus Leccinum and of the inhibitory activity of these compounds against the formation of osteoclasts.


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