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International Journal of Medicinal Mushrooms
IF: 1.423 5-Year IF: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Print: 1521-9437
ISSN Online: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v14.i5.40
pages 467-470

Activity of Crude Cold-Water Extract of the Culinary-Medicinal Oyster Mushroom, Pleurotus ostreatus (Jacq.:Fr.) P.Kumm. (Higher Basidiomycetes), and Timolol Maleate on Induced Ocular Hypertension

Joseph Kayefor Ebigwai
Department of Botany, University of Calabar, P.M.B. 1115, Calabar, Nigeria
Esther Aja Edu
Department of Botany, University of Calabar, P.M.B. 1115, Calabar, Nigeria
Edisua Hogan Itam
Department of Biochemistry, University of Calabar, Nigeria
Ann Jerry Mofunanya
Department of Botany, University of Calabar, P.M.B. 1115, Calabar, Nigeria

ABSTRACT

Aqueous crude cold-water extract from the fruiting body of the culinary-medicinal oyster mushroom Pleurotus ostreatus was assessed for activity against increased intra-ocular pressure (IOP) in mice. A 0.1% dexamethasone instillation was used to raise the intra-ocular pressure in the animals above the 21-mmHg threshold limit. The extract has intrinsic anti-hypertensive properties that are dose dependent. A comparison analysis indicated that 150 mg/mL of the crude extract produced 57.69% reduction in the intra-ocular pressure, while doses of 100 mg/ mL and 200 mg/mL produced 44.78% and 70.03% IOP reduction, respectively, compared with timolol maleate with 57.69%. The results were significant at 0.05 confidence limit (p < 0.05) when compared to a placebo and therefore support its use for the treatment of increased intra-ocular pressure.


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