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International Journal of Medicinal Mushrooms
IF: 1.423 5-Year IF: 1.525 SJR: 0.431 SNIP: 0.716 CiteScore™: 2.6

ISSN Print: 1521-9437
ISSN Online: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v8.i1.70
pages 57-61

Immunomodulatory Activity of Ganoderma lucidum (W.Curt.:Fr.) P. Karst. (Ling Zhi, Reishi) Polysaccharide Extract on Delayed Type Hypersensitivity

Shafi Mojadadi
Department of Immunology, School of Medical Sciences, Tarbiat Modares University, P.O. Box: 14115-111, Tehran; and Department of Microbiology & Immunology, School of Medicine, Kerman Medical University, Kerman, Iran
Massoumeh Ebtekar
Department of Immunology, School of Medical Sciences, Tarbiat Modares University, P.O. Box: 14115-111, Tehran, Iran
Zuhair Mohammad Hassan
Department of Immunology, School of Medical Sciences, Tarbiat Modares University, P.O. Box: 14115-111, Tehran, Iran

ABSTRACT

Ganoderma lucidum has been recognized as an immunomodulatory natural product. This study investigated the effect of G. lucidum polysaccharide extract (Gl-PS) on the proliferation of mouse lymphocytes and the DTH (delayed type hypersensitivity) response test. Initially, we examined Gl-PS effect on proliferation of mouse lymphocytes in vitro, and then cell-mediated immune response was studied using the DTH test. Results indicate that Gl-PS 0.1 μg/ml can significantly increase proliferation of mouse lymphocytes in vitro. Finally, evaluation of the effect of Gl-PS on DTH response indicates that Gl-PS 100 mg/kg can increase DTH response against SRBC in BALB/c mice. We conclude that Gl-PS has a potent immunomodulatory effect and can be used for potentiation of the immune system against diseases, such as cancer, and other diseases in which the immune response has been weakened.


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