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International Journal of Physiology and Pathophysiology
SJR: 0.116

ISSN Print: 2155-014X
ISSN Online: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

International Journal of Physiology and Pathophysiology

DOI: 10.1615/IntJPhysPathophys.v8.i4.50
pages 329-336

The Relationship between Epiphyseal and Gonadal Activities in Male Rats in Different Seasons

Valeriia Hnatiuk
National University of Pharmacy, Kharkiv, Ukraine
Nadiia Kononenko
National University of Pharmacy, Kharkiv, Ukraine

ABSTRACT

We studied the functional activities of the pineal gland and the gonads in male rats of different age in different seasons by determining the levels of melatonin and testosterone in the blood serum. It has been found that the highest levels of melatonin are observed in male rats in summer and winter, and the lowest − in autumn. The lowest level of melatonin was detected in the group of 9 months old rats (127.28 + 5.11 pmol/l) that was lower by 22% than the level of melatonin in 3 months old rats (P ≤ 0.05), and by 20% lower the level of melatonin in 15 months old rats (P ≤ 0.05). When comparing the levels of melatonin in different age groups, the highest level was detected in 3 months old rats (corresponds to human's 14), the lowest level was observed in 20 months old rats (corresponds to human's 55 − 56). At the same time, low level of melatonin was defined in rats aged 9 months in the autumn (corresponds to human's 29 − 30). In the study of testosterone levels in different seasons it was found that the highest level in all age groups was in autumn, and the lowest – in winter. When comparing the levels of testosterone in different age groups, it turned out that the highest level of testosterone was observed in the blood of male 9 months old and 15 months old rats, which corresponds to the human age of 29 − 30 and 43 − 44. Significant differences between the levels of testosterone in the rat groups of the reproductive age (3, 9, and 15 months) are observed only in the autumn; while there are no any significant differences between the levels of testosterone in spring and summer. The degree of correlation differed in rats of different age in different seasons: the highest correlation between the levels of melatonin and testosterone was detected in rats at the age of 9 months in autumn. The correlation coefficients in rats at the age of 20 months are weak, from 0.05 in spring to 0.17 in autumn, which shows age-related changes in neurohormonal regulation, which occur with age.


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