Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
International Journal of Physiology and Pathophysiology
SJR: 0.116

ISSN Print: 2155-014X
ISSN Online: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

International Journal of Physiology and Pathophysiology

DOI: 10.1615/IntJPhysPathophys.v8.i4.70
pages 347-353

Single-Channel Ion Currents in the Nuclear Envelope of Rat Cardiomyocytes

O. A. Kotyk
Bogomolets Institute of Physiology, NASU, Kyiv, Ukraine
Anna B. Kotliarova
Bogomolets Institute of Physiology, NASU, Kyiv, Ukraine
A. O. Polishchuk
Bogomolets Institute of Physiology, NASU, Kyiv, Ukraine
Sergey M. Marchenko
Bogomoletz Institute of Physiology of the National Academy of Sciences of Ukraine, Kyiv

ABSTRACT

Using the patch clamp technique in nucleus attached configuration, we have found that the nuclear membrane of rat cardiomyocytes contains different types of ion channels with conductances in the range from 10 to 400 pSm. In particular, we recorded inositol 1,4,5-trisphosphate receptors with conductance of (384 ± 5) pS, as well as cation channels with conductance of (209 ± 13) pS which are similar to large-conductance (LCC)-channels, previously reported in neurons. In addition, we have found at least two types of ion channels with significantly higher conductance than that of LCC-channels, and several types of ion channels with lower conductance (10 – 90 pSm).


Articles with similar content:

Contribution of Phosphoinositide Signaling Pathway to Opioid-Mediated Control of P2X3 Receptors in the Primary Sensory Neurons
International Journal of Physiology and Pathophysiology, Vol.7, 2016, issue 3
Igor V. Chizhmakov, Oleg O. Krishtal, Vyacheslav B. Kulyk, Oleksandr P. Maximyuk, Tetyana M. Volkova
COMPARATIVE ANALYSIS OF THE EXERGETIC PERFORMANCE OF A HOUSEHOLD REFRIGERATOR USING R134a AND R600a
International Journal of Energy for a Clean Environment, Vol.19, 2018, issue 1-2
Sunday O. Oyedepo, D. S. Adelekan, S. A. Akinlabi, Taiwo O. Babarinde, O. S. Ohunakin, D. M. Madyira
Calix[4]arenes as Modulators of Energy- Dependent Ca2+-Accumulation and Functioning of the Electron Transport Chain in Smooth Muscle Mitochondria
International Journal of Physiology and Pathophysiology, Vol.8, 2017, issue 3
Alexander Ju. Chunikhin, Roman V. Rodik, Victor I. Kalchenko, Hanna V. Danylovych, Yuriy V. Danylovych
Iron Accumulation and Expression of Iron-Related Proteins Following Murine Exposure to Crocidolite
Journal of Environmental Pathology, Toxicology and Oncology, Vol.28, 2009, issue 2
Tim D. Oury, Cheryl L. Fattman, Andrew J. Ghio, Roderick J. Tan, Kathleen Ghio
Analysis of Quantal Characteristics of GABA Release during Short-Term Depression and Facilitation of Synaptic Transmission
International Journal of Physiology and Pathophysiology, Vol.8, 2017, issue 3
Oksana P. Kolesnyk, Mycola S. Veselovsky, Svetlana A. Fedulova