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International Journal of Physiology and Pathophysiology

Published 4 issues per year

ISSN Print: 2155-014X

ISSN Online: 2155-0158

SJR: 0.116

Activation of NF-kB under the Metabolic Syndrome

Volume 3, Issue 3, 2012, pp. 287-297
DOI: 10.1615/IntJPhysPathophys.v3.i3.90
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ABSTRACT

The paper examines the formation of evolutionary advanced set of causal factors that may cause new pathological state being implemented through evolutionary fixed typical pathological processes. The analysis of the concept of "metabolic syndrome" and its components has been performed. The author points to the correlation between the insulin resistance, chronic inflammation, hypertension, endothelial dysfunction and dyslipidemia as manifestations of a pathological process, the central molecular basis of which is activation of NF-kB. It has been proposed to formulate the concept of permanent (long-term and low-grade) NF-kB activation as a possible model of a pathological process.

CITED BY
  1. SU CHUNLIN, CHEN MIN, HUANG HAIYAN, LIN JINFANG, Testosterone enhances lipopolysaccharide-induced interleukin-6 and macrophage chemotactic protein-1 expression by activating the extracellular signal-regulated kinase 1/2/nuclear factor-κB signalling pathways in 3T3-L1 adipocytes, Molecular Medicine Reports, 12, 1, 2015. Crossref

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