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International Journal of Physiology and Pathophysiology

Published 4 issues per year

ISSN Print: 2155-014X

ISSN Online: 2155-0158

SJR: 0.116

Efficiency of ω-3 Polyunsaturated Fatty Acids at Physical Exercise

Volume 4, Issue 4, 2013, pp. 273-283
DOI: 10.1615/IntJPhysPathophys.v4.i4.10
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ABSTRACT

Based on the results of quantum-chemical studies with the analysis of the atomic structure of the molecule, it has been shown that ω-3 polyunsaturated fatty acids have distinct antioxidant and membranoprotective properties, similar to tocopherol, a bioantioxidant carotenoid. Epadol, the drug made on the base of ω-3 polyunsaturated fatty acids, has been shown to inhibit simultaneously lipid peroxidation (which is manifested as a decrease in malonic dialdehyde content) and to promote an improvement of the antioxidant defense, represented by an increase in the concentration of reduced glutathione in erythrocyte membranes. The use of this remedy for athletes results in a decrease in pro-oxidative-anti-oxidative ratio from 2.44 to 1.34, indicating the antioxidant properties of Epadol. However, the erythrocyte sorption capacity, which characterizes the functional properties of their membranes, when exposed to Epadol decreases from (35.04 ± 2.23)% to (25.3 ± 1.07)%, which counteracts to aggregation of erythrocytes. An expediency of using Epadol, the domestic medical remedy, in practice of athletes training to improve structural and functional status of the cell membranes and prevent uncontrolled apoptosis has being discussed.

CITED BY
  1. Gunina Larisa, Implementation of the ergogenic action of antioxidative agents, Sporto mokslas / Sport Science, 3, 81, 2015. Crossref

  2. Gunina Larisa, Milashyus Kazys, Mechanisms of Antioxidant’s Action on the Physical Performance of Athletes, Ukraïnsʹkij žurnal medicini, bìologìï ta sportu, 1, 1, 2016. Crossref

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