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International Journal of Physiology and Pathophysiology

Published 4 issues per year

ISSN Print: 2155-014X

ISSN Online: 2155-0158

SJR: 0.116

Arginine Exchange and Nitric Oxide Synthesis in Youths under Adaptation to Physical Exercise in Training and Competitive Periods

Volume 2, Issue 4, 2011, pp. 309-319
DOI: 10.1615/IntJPhysPathophys.v2.i4.20
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ABSTRACT

A survey of 29 trained and untrained youths aged 18 to 20 years was carried out. It has been shown that the optimal level of adaptation of a trained body to prolonged and intense physical exercise is provided by the activation of not only the constitutive calcium-dependent nitric oxide synthesis, but also by oxidative arginase metabolism of arginine, which yields a range of important low-molecular bioregulators and antioxidants, including urea. Significant reduction in the functionality of the body of trained youths at the end of competition period and as a consequence the manifestation of disadaptation signs correlates with increased oxidative calcium independent nitric oxide synthesis and its non-oxidative synthesis due to reutilization of stable circulating NO metabolites.

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