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International Journal of Physiology and Pathophysiology

Published 4 issues per year

ISSN Print: 2155-014X

ISSN Online: 2155-0158

SJR: 0.116

Effect of L-Arginine − NO System on Prooxidant-Antioxidant Balance in Erythrocytes of Rats under Alcohol Intoxication

Volume 8, Issue 3, 2017, pp. 231-240
DOI: 10.1615/IntJPhysPathophys.v8.i3.40
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ABSTRACT

The changes in the activities of antioxidant enzymes (superoxide dismutase, catalase) and NO-synthase (NOS), the content of stable metabolic products of nitric oxide and lipid peroxidation products in erythrocytes of rats under alcoholic intoxication were examined. It has been revealed that in animals with alcohol intoxication treated with L-arginine, the main substrate for NOS, the activity of antioxidant defense enzymes increased twice against the background of reduced amount of TBA-positive products. In erythrocyte hemolysates of rats with alcohol intoxication, the value of total NOS activity decreased by 65% compared to control. Non-selective inhibitor Nω – nitro-L-arginine methyl ester (L-NAME), which is a structural analog of L-arginine, reduced the initial level of total NOS activity by 23.4% in the control and by 25% under pathological state. The L-arginine consumption by rats resulted in increasing NOS total activity in two groups under study. The results testify that L-arginine has antioxidant properties, whereas L-NAME exerts a slight stabilizing effect.

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