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International Journal of Physiology and Pathophysiology

Published 4 issues per year

ISSN Print: 2155-014X

ISSN Online: 2155-0158

SJR: 0.116

Pathological Remodeling of Myocardium in Spontaneous Hypertensive Rats with Experimental Diabetes Mellitus: Role of Mitochondrial Dysfunction

Volume 6, Issue 2, 2015, pp. 139-150
DOI: 10.1615/IntJPhysPathophys.v6.i2.60
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ABSTRACT

The expression of cardiotrophin-1, annexin V, titin and type I collagen was investigated in the myocardium of normotensive Wistar rats and spontaneous hypertensive rats with experimental diabetes and without it. The Ca2+ -induced mitochondrial permeability transition pore was assessed in the mitochondria isolated from rat hearts. The content of cardiotrophin-1, annexin V and type I collagen in spontaneous hypertensive rats with diabetes was higher compared to normotensive and diabetic rats. The cardiac titin level was 27% lower in animals with hypertension and diabetes compared with spontaneous hypertensive rats without diabetes. The changes in cardiotrophin-1, annexin V, titin and type I collagen expression were associated with higher sensitivity of mitochondrial pore to Ca2+ in the myocardium of spontaneous hypertensive rats with diabetes mellitus.

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