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International Journal of Physiology and Pathophysiology

Published 4 issues per year

ISSN Print: 2155-014X

ISSN Online: 2155-0158

SJR: 0.116

The Association of A−1082G Polymorphism of IL-10 and (A−308G) Polymorphism of TNFα Genes with Bone Density in Elderly Women

Volume 1, Issue 4, 2010, pp. 315-327
DOI: 10.1615/IntJPhysPathophys.v1.i4.20
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ABSTRACT

We studied the association between bone mineral density and (A −1082G) polymorphism of IL-10 and (A−308G) polymorphism of TNFα genes. SNP-polymerase chain reaction was used. The study failed to find significant association of A−308G TNFα polymorphism and bone state in postmenopausal women. The patients with AA genotype of A−1082G IL-10 gene have significantly lower indices of bone mineral density comparing with G allele carriers (GG/AG). This association remained true for data of bone mineral density of total body, and separate parts of skeleton: lumbar spine, femoral neck, Ward's triangle of total femur. Our study indicates that A−308G polymorphism of TNFα gene is not associated with indices of bone mineral density in postmenopausal women. However, there is strong evidence that women, carriers of AA genotype of A−1082G polymorphism of IL-10 gene have significantly lower indices of bone mineral density. This indicates the potential for predictive genetic testing of osteoporosis risk. Analyses of gene combination IL-10 G−1082G and TNFα G−308G ('antiinflammatory genotype') did not show any significant association of this genotype with bone characteristics, which shows low predictive value of this combination for diagnostics of osteoporosis.

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