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International Journal of Physiology and Pathophysiology

Published 4 issues per year

ISSN Print: 2155-014X

ISSN Online: 2155-0158

SJR: 0.116

Influence of Endothelial Nitric Oxide Synthase T−786→C Promoter Polymorphism on Integral Parameters of Functional Condition of Arterial Vessels

Volume 1, Issue 3, 2010, pp. 277-286
DOI: 10.1615/IntJPhysPathophys.v1.i3.90
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ABSTRACT

Frequency of eNOS Т−786→С promoter polymorphism in 325 patients with acute coronary syndrome and 104 control persons and influence of this polymorphism on reactive hyperemia and arterial stiffness were determined. Interrelation between T/T homozygous, T/С heterozygous and С/С homozygous was 42.5 %, 41.2 % and 16.3 % correspondingly (in control − 40.4 %, 53.8 % and 5.8 %; Р < 0.01 by χ2-test). Higher degree of brachial arteries diameter increase in response to ischemia was estimated in patients with Т/Т genotype: 8.03 ± 0.71 % compared to 5.55 ± 0.92 % in Т/С (Р < 0.05) and 5.30 ± 1.21 % in С/С genotypes (P < 0.05). Speed of pulse wave spreading on carotid-radial and carotid-femoral arteries segments was also depended on patients genotype: in Т/Т genotype was 9.10 ± 0.15 and 8.68 ± 0.26 correspondingly, in Т/С - 9.38 ± 0.18 and 8.74 ± 0.21, and in С/С carriers - 9.71 ± 0.22 and 10.02 ± 0.71 (P < 0.05). Thus, obtained data indicate on significantly influencing of Т−786→С promoter polymorphism on integral parameters of functional condition of arterial vessels.

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