Library Subscription: Guest
Critical Reviews™ in Eukaryotic Gene Expression

Published 6 issues per year

ISSN Print: 1045-4403

ISSN Online: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

Indexed in

Current State of Immunosuppression: Past, Present, and Future

Volume 25, Issue 2, 2015, pp. 113-134
DOI: 10.1615/CritRevEukaryotGeneExpr.2015011421
Get accessGet access

ABSTRACT

The success of solid-organ transplantation was made possible by recognizing that destruction of the graft is caused by an alloimmune-mediated process. For the past decade, immunosuppressive protocols have used a combination of drugs that significantly decreased the rate of acute organ rejection. Despite advances in surgical and medical care of recipients of solid-organ transplants, long-term graft survival and patient survival have not improved during the past 2 decades. Current immunosuppression protocols include a combination of calcineurin inhibitors, such as tacrolimus, and antiproliferative agents (most commonly mycophenolate mofetil), with or without different dosing regimens of corticosteroids. Mammalian target of rapamycin inhibitors were introduced to be used in combination with cyclosporine-based therapy, but they did not gain much acceptance because of their adverse event profile. Belatacept, a costimulatory inhibitor, is currently being studied in different regimens in an effort to replace the use of calcineurin inhibitors to induce tolerance and to improve long-term outcomes. Induction therapy is now being used in more than 90% of kidney transplants and more than 50% cases of other solid-organ transplantation such as lung, heart, and intestinal transplants. As a result of these combination immunosuppressive (IS) therapy protocols, not only the incidence but also the intensity of episodes of acute rejection have decreased markedly, and at present 1-year graft and patient survival is almost 98% for kidney transplant recipients and approximately greater than 80% for heart and lung transplants. Evolving concepts include the use of donor-derived bone marrow mesenchymal cells to induce tolerance, to minimize the use of maintenance IS agents, and to prevent the development of adverse events associated with long-term use of maintenance IS therapy.

CITED BY
  1. La Muraglia G.M., O'Neil M.J., Madariaga M.L., Michel S.G., Mordecai K.S., Allan J.S., Madsen J.C., Hanekamp I.M., Preffer F.I., A novel approach to measuring cell-mediated lympholysis using quantitative flow and imaging cytometry, Journal of Immunological Methods, 427, 2015. Crossref

  2. Rancic Nemanja, Dragojevic-Simic Viktorija, Vavic Neven, Kovacevic Aleksandra, Segrt Zoran, Djordjevic Natasa, Economic Evaluation of Pharmacogenetic Tests in Patients Subjected to Renal Transplantation: A Review of Literature, Frontiers in Public Health, 4, 2016. Crossref

  3. Haidar G., Crespo M., Maximous S., Lendermon E., Clancy C.J., Nguyen M.H., Invasive Tracheobronchial Aspergillosis in a Lung Transplant Recipient Receiving Belatacept as Salvage Maintenance Immunosuppression: A Case Report, Transplantation Proceedings, 48, 1, 2016. Crossref

  4. Sá Helena, Leal Rita, Rosa Manuel Santos, Renal transplant immunology in the last 20 years: A revolution towards graft and patient survival improvement, International Reviews of Immunology, 36, 3, 2017. Crossref

  5. Kurzawski Mateusz, Malinowski Damian, Dziewanowski Krzysztof, Droździk Marek, Analysis of common polymorphisms within NR1I2 and NR1I3 genes and tacrolimus dose-adjusted concentration in stable kidney transplant recipients, Pharmacogenetics and Genomics, 27, 10, 2017. Crossref

  6. Tan Loh Teng-Hern, Chan Kok-Gan, Khan Tahir Mehmood, Bukhari Sarah Ibrahim, Saokaew Surasak, Duangjai Acharaporn, Pusparajah Priyia, Lee Learn-Han, Goh Bey-Hing, Streptomyces sp. MUM212 as a Source of Antioxidants with Radical Scavenging and Metal Chelating Properties, Frontiers in Pharmacology, 8, 2017. Crossref

  7. Rancic Nemanja, Vavic Neven, Obrencevic Katarina, Pilipovic Filip, Dragojevic-Simic Viktorija, Tacrolimus Utilization and Expenditure in Serbia, Frontiers in Public Health, 5, 2017. Crossref

  8. Holt Curtis D., Overview of Immunosuppressive Therapy in Solid Organ Transplantation, Anesthesiology Clinics, 35, 3, 2017. Crossref

  9. Koo Jamie, Wang Hanlin L., Acute, Chronic, and Humoral Rejection, Surgical Pathology Clinics, 11, 2, 2018. Crossref

  10. Wong Grace Lai-Hung, Yuen Becky Wing-Yan, Chan Henry Lik-Yuen, Tse Yee-Kit, Yip Terry Cheuk-Fung, Lam Kelvin Long-Yan, Lui Grace Chung-Yan, Wong Vincent Wai-Sun, Negro Francesco, Impact of dose and duration of corticosteroid on the risk of hepatitis flare in patients with chronic hepatitis B, Liver International, 39, 2, 2019. Crossref

  11. Salman J., Jansson K., Siemeni Th., Sommer W., Knoefel A.-K., Ahrens L., Nakagiri T., Ius F., Tudorache I., Kruse B., Thissen S., Jonigk D., Strüber M., Haverich A., Warnecke G., Avsar M., Role for primary immunosuppression with everolimus after pulmonary transplantation, Transplant Immunology, 49, 2018. Crossref

  12. Aziz Fahad, Garg Neetika, Parajuli Sandesh, Djamali Arjang, Stein James H., Mandelbrot Didier, Lipid lowering in dialysis patients with cardiovascular disease who are awaiting kidney transplantation, Clinical Transplantation, 2018. Crossref

  13. Chang Jessica B., Rifkin William J., Soares Marc A., Duckworth April, Rao Nakul, Low Yee Cheng, Massie Jonathan P., Rabbani Piul S., Saadeh Pierre B., Ceradini Daniel J., Ex Vivo Major Histocompatibility Complex I Knockdown Prolongs Rejection-free Allograft Survival, Plastic and Reconstructive Surgery - Global Open, 6, 6, 2018. Crossref

  14. Rottembourg Jacques, Rostoker Guy, L’utilisation de génériques en transplantation : vers des solutions rationnelles et sures !, La Presse Médicale, 47, 3, 2018. Crossref

  15. Zhao Zhi-Qing, Treatment with dietary cyclosporine has no direct effect on myocardial fibrosis and hypertension in mice, MOJ Drug Design Development & Therapy, 1, 3, 2017. Crossref

  16. Kitamura Mineaki, Mochizuki Yasushi, Miyata Yasuyoshi, Obata Yoko, Mitsunari Kensuke, Matsuo Tomohiro, Ohba Kojiro, Mukae Hiroshi, Yoshimura Atsutoshi, Nishino Tomoya, Sakai Hideki, Pathological Characteristics of Periodontal Disease in Patients with Chronic Kidney Disease and Kidney Transplantation, International Journal of Molecular Sciences, 20, 14, 2019. Crossref

  17. Modo Michel, Bioscaffold-Induced Brain Tissue Regeneration, Frontiers in Neuroscience, 13, 2019. Crossref

  18. Wong Grace Lai-Hung, Wong Vincent Wai-Sun, Yuen Becky Wing-Yan, Tse Yee-Kit, Yip Terry Cheuk-Fung, Luk Hester Wing-Sum, Lui Grace Chung-Yan, Chan Henry Lik-Yuen, Risk of hepatitis B surface antigen seroreversion after corticosteroid treatment in patients with previous hepatitis B virus exposure, Journal of Hepatology, 72, 1, 2020. Crossref

  19. Houben Rudolph H., Aleff Ross A., Friedrich Patricia F., Shin Alexander Y., Wieben Eric D., van Wijnen Andre J., Bishop Allen T., Transplant chimerism in porcine structural vascularized bone allotransplants, Gene, 747, 2020. Crossref

  20. Li Jinpeng, Gao Rongfen, Wu Gaosong, Wu Xiaolin, Liu Zeming, Wang Hongjing, Huang Yihui, Pan Zhenyu, Chen Jincao, Wu Xiaohui, Clinical characteristics of emergency surgery patients infected with coronavirus disease 2019 (COVID-19) pneumonia in Wuhan, China, Surgery, 168, 3, 2020. Crossref

  21. Resch Thomas, Cardini Benno, Oberhuber Rupert, Weissenbacher Annemarie, Dumfarth Julia, Krapf Christoph, Boesmueller Claudia, Oefner Dietmar, Grimm Michael, Schneeberger Sefan, Transplanting Marginal Organs in the Era of Modern Machine Perfusion and Advanced Organ Monitoring, Frontiers in Immunology, 11, 2020. Crossref

  22. Cao Peng, Sun Zejia, Feng Chang, Zhang Jiandong, Zhang Feilong, Wang Wei, Zhao Yong, Myeloid-derived suppressor cells in transplantation tolerance induction, International Immunopharmacology, 83, 2020. Crossref

  23. Tron Camille, Coste Gwendal, Lalanne Sébastien, Bernard Aurélie, Jan Yann-Gaël, Ferrand-Sorre Marie-José, Verdier Marie-Clémence, Bellissant Eric, Lemaitre Florian, A simple and fast liquid chromatography tandem mass spectrometry method to determine cyclosporine A concentrations in endomyocardial biopsies, Journal of Pharmaceutical and Biomedical Analysis, 193, 2021. Crossref

  24. Chen Yi-Wen, Wei Jeng, Chen Hwei-Ling, Cheng Ching-Hui, Hou I-Ching, Developing a Heart Transplantation Self-Management Support Mobile Health App in Taiwan: Qualitative Study, JMIR mHealth and uHealth, 8, 8, 2020. Crossref

  25. Ballardin Bárbara Soldatelli, Mobile Rafael Zancan, Torres‐Pereira Cassius Carvalho, Schussel Juliana Lucena, Medication‐related fibrovascular hyperplasia lesion in tongue: Case report, Special Care in Dentistry, 40, 5, 2020. Crossref

  26. Chen Bing, Lu Jia-Qian, Shao Kun, Zhai Xiao-Hui, An Hui-Min, Shi Hao-Qiang, Zhou Pei-Jun, Establishment of a Liquid Chromatography-Tandem Mass Spectrometry Method for the Determination of Immunosuppressant Levels in the Peripheral Blood Mononuclear Cells of Chinese Renal Transplant Recipients, Therapeutic Drug Monitoring, 42, 5, 2020. Crossref

  27. Iglesias Marcos, Khalifian Saami, Oh Byoung C., Zhang Yichuan, Miller Devin, Beck Sarah, Brandacher Gerald, Raimondi Giorgio, A short course of tofacitinib sustains the immunoregulatory effect of CTLA4‐Ig in the presence of inflammatory cytokines and promotes long‐term survival of murine cardiac allografts, American Journal of Transplantation, 21, 8, 2021. Crossref

  28. Lúcio Maria João, Horta Ricardo, Hand Transplantation—Risks and Benefits, Journal of Hand and Microsurgery, 13, 04, 2021. Crossref

  29. Podestà Manuel Alfredo, Remuzzi Giuseppe, Casiraghi Federica, Mesenchymal Stromal Cell Therapy in Solid Organ Transplantation, Frontiers in Immunology, 11, 2021. Crossref

  30. Zhao Lingfei, Hu Chenxia, Han Fei, Chen Dajin, Cheng Jun, Wu Jianyong, Peng Wenhan, Chen Jianghua, Induction therapy with mesenchymal stromal cells in kidney transplantation: a meta-analysis, Stem Cell Research & Therapy, 12, 1, 2021. Crossref

  31. Ballardin Bárbara Soldatelli, Mobile Rafael Zancan, Coracin Fábio Luiz, Ribeiro Lisandro Lima, Bonfim Carmem Maria Sales, Schussel Juliana Lucena, Torres‐Pereira Cassius, A case series of medication‐related fibrovascular hyperplasia following hematopoietic stem cell transplantation for Fanconi anemia, Pediatric Transplantation, 25, 6, 2021. Crossref

  32. Sahman Majda, Mugosa Snezana, Rancic Nemanja, Utilization of Mycophenolic Acid, Azathioprine, Tacrolimus, Cyclosporin, Sirolimus, and Everolimus: Multinational Study, Frontiers in Public Health, 9, 2021. Crossref

  33. Pacheco Mariana P, Carneiro-D'Albuquerque Luiz Augusto, Mazo Daniel F, Current aspects of renal dysfunction after liver transplantation, World Journal of Hepatology, 14, 1, 2022. Crossref

  34. Yip Terry Cheuk-Fung, Gill Madeleine, Wong Grace Lai-Hung, Liu Ken, Management of hepatitis B virus reactivation due to treatment of COVID-19, Hepatology International, 16, 2, 2022. Crossref

  35. Overvad Maria, Koch Anders, Jespersen Bente, Gustafsson Finn, Krause Tyra Grove, Hansen Christian Holm, Ethelberg Steen, Obel Niels, Outcomes following SARS‐CoV ‐2 infection in individuals with and without solid organ transplantation—A Danish nationwide cohort study , American Journal of Transplantation, 2022. Crossref

Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections Prices and Subscription Policies Begell House Contact Us Language English 中文 Русский Português German French Spain