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Critical Reviews™ in Eukaryotic Gene Expression

Published 6 issues per year

ISSN Print: 1045-4403

ISSN Online: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

Indexed in

Characteristics and Tissue Regeneration Properties of Gingiva-Derived Mesenchymal Stem Cells

Volume 25, Issue 2, 2015, pp. 135-144
DOI: 10.1615/CritRevEukaryotGeneExpr.2015012539
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ABSTRACT

Mesenchymal stem cells (MSCs) have 2 specific characteristics: self-renewal and multi- or pluripotency. Extensive studies have demonstrated the regenerative capability of MSCs both in vitro and in vivo. Gingiva-derived MSCs (GMSCs) represent a unique population of MSCs that can be easily isolated and obtained. GMSCs, which maintain a normal karyotype and telomerase activity in long-term cultures, display a stable phenotype and rapidly proliferate in vitro. In addition, GMSCs can be induced to differentiate into osteogenic, chondrogenic, and adipogenic lineages. Therefore, GMSCs are a promising alternative cell source for tissue regeneration in dentistry. In this article we review studies of the characterization, differentiation capacities, and regenerative role of GMSCs derived from the gingiva of humans and other species, focusing on the mechanisms of differentiation and tissue regeneration of human GMSCs. We anticipate that GMSC-based therapies will significantly contribute to regenerative medicine for the treatment of human dental diseases and improve human health.

CITED BY
  1. Zhao Ningbo, Wang Xin, Qin Lei, Zhai Min, Yuan Jing, Chen Ji, Li Dehua, Effect of hyaluronic acid in bone formation and its applications in dentistry, Journal of Biomedical Materials Research Part A, 104, 6, 2016. Crossref

  2. Wani Mohan R., Human Gingiva: A Promising Source of Mesenchymal Stem Cells for Cell Therapy and Regenerative Medicine, in Regenerative Medicine: Laboratory to Clinic, 2017. Crossref

  3. Millan Carola, Vivanco Juan F., Benjumeda-Wijnhoven Isabel M., Bjelica Suncica, Santibanez Juan F., Mesenchymal Stem Cells and Calcium Phosphate Bioceramics: Implications in Periodontal Bone Regeneration, in Cell Biology and Translational Medicine, Volume 3, 1107, 2018. Crossref

  4. Giacomelli Chiara, Natali Letizia, Nisi Marco, De Leo Marinella, Daniele Simona, Costa Barbara, Graziani Filippo, Gabriele Mario, Braca Alessandra, Trincavelli M. Letizia, Martini Claudia, Negative effects of a high tumour necrosis factor-α concentration on human gingival mesenchymal stem cell trophism: the use of natural compounds as modulatory agents, Stem Cell Research & Therapy, 9, 1, 2018. Crossref

  5. Kang Wenyan, Ji Xiaoli, Zhang Xiujun, Tang Di, Feng Qiang, Persistent Exposure to Fusobacterium nucleatum Triggers Chemokine/Cytokine Release and Inhibits the Proliferation and Osteogenic Differentiation Capabilities of Human Gingiva-Derived Mesenchymal Stem Cells, Frontiers in Cellular and Infection Microbiology, 9, 2019. Crossref

  6. Vidoni Chiara, Ferraresi Alessandra, Secomandi Eleonora, Vallino Letizia, Gardin Chiara, Zavan Barbara, Mortellaro Carmen, Isidoro Ciro, Autophagy drives osteogenic differentiation of human gingival mesenchymal stem cells, Cell Communication and Signaling, 17, 1, 2019. Crossref

  7. Henckes Nicole Andréa Corbellini, Festa Jaquelline Christine Dias, Faleiro Dalana, Medeiros Helouise Richardt, Guerra Nayrim Brizuela, dos Santos Luis Alberto Loureiro, Terraciano Paula Barros, Passos Eduardo Pandolfi, de Oliveira Fernanda dos Santos, Cirne-Lima Elizabeth Obino, Tissue-engineered solution containing cells and biomaterials—an in vitro study: A perspective as a novel therapeutic application, The International Journal of Artificial Organs, 42, 6, 2019. Crossref

  8. Koltsova A. M., Zenin V. V., Turilova V. I., Yakovleva T. K., Poljanskaya G. G., Isolation and Characterization of Mesenchymal Stem Cells from Human Gingiva, Cell and Tissue Biology, 14, 1, 2020. Crossref

  9. Behm Christian, Blufstein Alice, Abhari Setareh Younes, Koch Christoph, Gahn Johannes, Schäffer Christina, Moritz Andreas, Rausch-Fan Xiaohui, Andrukhov Oleh, Response of Human Mesenchymal Stromal Cells from Periodontal Tissue to LPS Depends on the Purity but Not on the LPS Source, Mediators of Inflammation, 2020, 2020. Crossref

  10. Li Pei, Zhao Yuming, Ge Lihong, Therapeutic effects of human gingiva-derived mesenchymal stromal cells on murine contact hypersensitivity via prostaglandin E2–EP3 signaling, Stem Cell Research & Therapy, 7, 1, 2016. Crossref

  11. Hollý Dušan, Klein Martin, Mazreku Merita, Zamborský Radoslav, Polák Štefan, Danišovič Ľuboš, Csöbönyeiová Mária, Stem Cells and Their Derivatives—Implications for Alveolar Bone Regeneration: A Comprehensive Review, International Journal of Molecular Sciences, 22, 21, 2021. Crossref

  12. Lei Tong, Zhang Xiaoshuang, Du Hongwu, Ballini Andrea, Characteristics, Classification, and Application of Stem Cells Derived from Human Teeth, Stem Cells International, 2021, 2021. Crossref

  13. Yan Xin, Yan Fei, Mohammed Hanan Abdulfattah Gamal, Liu Ousheng, Choudhery Mahmood S., Maxillofacial-Derived Mesenchymal Stem Cells: Characteristics and Progress in Tissue Regeneration, Stem Cells International, 2021, 2021. Crossref

  14. Qi Lei, Liu Lu, Hu Yue, Li Jie, Li Jiayi, Cao Ningning, Zhu Fangxing, Shi Chaoji, Zhang Lei, Concentrated growth factor promotes gingival regeneration through the AKT/Wnt/β-catenin and YAP signaling pathways, Artificial Cells, Nanomedicine, and Biotechnology, 48, 1, 2020. Crossref

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