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Critical Reviews™ in Eukaryotic Gene Expression

Published 6 issues per year

ISSN Print: 1045-4403

ISSN Online: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

Indexed in

The Control of Bone Growth by Parathyroid Hormone, Leptin, & Statins

Volume 12, Issue 1, 2002, 30 pages
DOI: 10.1615/CritRevEukaryotGeneExpr.v12.i1.20
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ABSTRACT

There is a need for anabolic drugs that can stimulate bone growth, improve bone microarchitecture, accelerate fracture healing and thus restore bone strength to oteoporotics. The anabolic agents currently leading the way to the clinic are the parathroid hormone (PTH) and some of its adenylyl cyclase-stimulating fragments. Here we discuss what is known about the genes and their products that are stimulated by PTHR1 receptor signals and in four ways cause a large accumulation of bone-building osteoblasts. We will also discuss the currently controversial anabolic activity of the cholesterol-lowering statins and outline a possible mechanism by which they might stimulate BMP-2 expession and bone growth. Finally, we will present the growing evdence for the body’s “fat-o-stat” cytokine—leptin—indirectly restraining bone growth via a hypothalamic factor and at the same serving as a local autocrine/paracrine stimulator of osteoblast activity via IGF-I and an inhibitor of osteoclast generation by stimulating osteoblastic cells’ antiosteoclast OPG (osteoprotegerin) expression and reducing their proosteoclast RANKL expression.

CITED BY
  1. Xing Lianping, Boyce Brendan F., Regulation of apoptosis in osteoclasts and osteoblastic cells, Biochemical and Biophysical Research Communications, 328, 3, 2005. Crossref

  2. Whitfield James F., Morley Paul, Willick Gordon E., , 65, 2002. Crossref

  3. Andjelkovic Zlatibor, Katic Vuka, Mihailovic Dragan, Petrovic Aleksandar, Bubanovic Ivan, RANKL/RANK/osteoprotegerin system as novel therapeutic target in the treatment of primary bone tumors and osteolytic metastases, Archive of Oncology, 12, 2, 2004. Crossref

  4. Ribalta J., Efectos complementarios de las terapias farmacológicas, Clínica e Investigación en Arteriosclerosis, 16, 3, 2004. Crossref

  5. Tsai Andy, Stamoulis Catherine, Barber Ignasi, Kleinman Paul K., Infant lower extremity long bone growth rates: comparison of contemporary with early 20th century data using mixed effect models, American Journal of Human Biology, 29, 1, 2017. Crossref

  6. Virk Sohrab, Bertone Alicia L., Hussein Hayam Hamaz, Toth Jeffrey M., Kaido Mari, Khan Safdar, The temporal expression of adipokines during spinal fusion, The Spine Journal, 17, 12, 2017. Crossref

  7. Zallone Alberta, Teti Anna, Il tessuto osseo, in Osteoporosi e malattie metaboliche dell’osso, 2009. Crossref

  8. Koch Ute, Lehal Rajwinder, Radtke Freddy, Stem cells living with a Notch, Development, 140, 4, 2013. Crossref

  9. Pajcini K V, Speck N A, Pear W S, Notch signaling in mammalian hematopoietic stem cells, Leukemia, 25, 10, 2011. Crossref

  10. Whitfield James F., How to grow bone to treat osteoporosis and mend fractures, Current Rheumatology Reports, 5, 1, 2003. Crossref

  11. Galindo Mario, Pratap Jitesh, Young Daniel W., Hovhannisyan Hayk, Im Hee-Jeong, Choi Je-Yong, Lian Jane B., Stein Janet L., Stein Gary S., van Wijnen Andre J., The Bone-specific Expression of Runx2 Oscillates during the Cell Cycle to Support a G1-related Antiproliferative Function in Osteoblasts, Journal of Biological Chemistry, 280, 21, 2005. Crossref

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