Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
Critical Reviews™ in Eukaryotic Gene Expression
IF: 2.156 5-Year IF: 2.255 SJR: 0.649 SNIP: 0.599 CiteScore™: 3

ISSN Print: 1045-4403
ISSN Online: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.2013006641
pages 93-101

ANP-NPRA Signaling Pathway−A Potential Therapeutic Target for the Treatment of Malignancy

Zhilong Zhao
Department of Surgical Oncology, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China
Jia Zhang
Department of Thoracic Surgery, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China
Min Li
Department of Surgical Oncology, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China
Ya Yang
Department of Surgical Oncology, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China
Kai Sun
Department of Surgical Oncology, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China
Jiansheng Wang
Tianjin University

ABSTRACT

It was well established that the atrial natriuretic peptide (ANP)/natriuretic peptide receptor-A (NPRA) signaling pathway controls natriuretic, diuretic, vasorelaxant, and anti-proliferative responses in the regulation of the human cardiovascular system by previous studies. Yet in recent years, more and more evidence has shown that the ANP/NPRA signaling pathway plays an important role in human cancer. For example, NPRA is abundantly expressed on tumorigenic mouse and human prostate cancer (PCa) cells, but not in nontumorigenic prostate epithelial cells and down-regulation of NPRA-induced apoptosis in PCa cells. Dexamethasone can increase the expression of ANP markedly, and that is the reason why dexamethasone is the cornerstone in the treatment of multiple myeloma. NPRA deficiency can substantially protect C57BL/6 mice from lung, skin, and ovarian cancers. These results strongly suggest ANP and NPRA may play an anti-cancer and carcinogenesis role, respectively, and this signaling pathway could be a more potent target for cancer therapy. In light of these new insights, this review will summarize the structures, functions, and their regulation by cell signaling, and their different impacts on tumors.

KEY WORDS: ANP, NPRA, cancer, target, treatment

Articles with similar content:

Regulation of Cell Cycle Progression and Apoptosis by the Papillomavirus E6 Oncogene
Critical Reviews™ in Eukaryotic Gene Expression, Vol.14, 2004, issue 3
Xueli Fan, Jason J. Chen
The Yin-Yang of KIR3DL1/S1: Molecular Mechanisms and Cellular Function
Critical Reviews™ in Immunology, Vol.33, 2013, issue 3
Geraldine M. O'Connor, Daniel W. McVicar
Acquired T-Cell Immunodeficiency in Thymoma Patients
Critical Reviews™ in Immunology, Vol.36, 2016, issue 4
Paul Fisch, Petros Christopoulos
Role of GLI1 and NDRG1 in Increased Resistance to Apoptosis Induction
Journal of Environmental Pathology, Toxicology and Oncology, Vol.34, 2015, issue 3
William N. Rom, Yukio Hosomi, Kam-Meng Tchou-Wong, Minori Koshiji, Yiqun Mo, Feng Wu
Back to the Light Side: The Role of Mechanotransduction in the Paradoxical Response to Checkpoint Inhibitors in Cancer Patients
Critical Reviews™ in Immunology, Vol.39, 2019, issue 3
Eslam Abbas, Tamer Z. Salem