Published 6 issues per year
ISSN Print: 1045-4403
ISSN Online: 2162-6502
Indexed in
Roles of Protein N-Myristoylation and Translational Medicine Applications
ABSTRACT
Protein N-myristoylation is a ubiquitous cotranslational and posttranslational modification catalyzed by myristoyl CoA:protein N-myristoyltransferase (NMT), which attaches myristate, a rare 14-carbon saturated fatty acid, to an N-terminal glycine of some eukaryotic and virus proteins. This protein modification triggers dynamic protein−protein and protein−membrane interactions implicated in diverse physiological processes. This review summarizes the NMT catalytic mechanism and demyristoylation. Of special interest are the primary roles of N-myristoylated protein in signaling, protein targeting, tumorigenesis, apoptosis, virus assembly, and morphology change, as well as the regulation of N-myristoylation and NMT inhibitors.
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Khan Sheeza, Bhat Ajaz A., Nonenzymatic Posttranslational Protein Modifications: Mechanism and Associated Disease Pathologies, in Protein Modificomics, 2019. Crossref
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Kersten Christian, Fleischer Edmond, Kehrein Josef, Borek Christoph, Jaenicke Elmar, Sotriffer Christoph, Brenk Ruth, How To Design Selective Ligands for Highly Conserved Binding Sites: A Case Study Using N-Myristoyltransferases as a Model System, Journal of Medicinal Chemistry, 63, 5, 2020. Crossref