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Critical Reviews™ in Eukaryotic Gene Expression

Published 6 issues per year

ISSN Print: 1045-4403

ISSN Online: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

Indexed in

Roles of Protein N-Myristoylation and Translational Medicine Applications

Volume 25, Issue 3, 2015, pp. 259-268
DOI: 10.1615/CritRevEukaryotGeneExpr.2015013978
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ABSTRACT

Protein N-myristoylation is a ubiquitous cotranslational and posttranslational modification catalyzed by myristoyl CoA:protein N-myristoyltransferase (NMT), which attaches myristate, a rare 14-carbon saturated fatty acid, to an N-terminal glycine of some eukaryotic and virus proteins. This protein modification triggers dynamic protein−protein and protein−membrane interactions implicated in diverse physiological processes. This review summarizes the NMT catalytic mechanism and demyristoylation. Of special interest are the primary roles of N-myristoylated protein in signaling, protein targeting, tumorigenesis, apoptosis, virus assembly, and morphology change, as well as the regulation of N-myristoylation and NMT inhibitors.

CITED BY
  1. Junaid Muhammad, Almuqri Eman Abdullah, Liu Junjun, Zhang Houjin, Salsbury Freddie, Analyses of the Binding between Water Soluble C60 Derivatives and Potential Drug Targets through a Molecular Docking Approach, PLOS ONE, 11, 2, 2016. Crossref

  2. Khan Sheeza, Bhat Ajaz A., Nonenzymatic Posttranslational Protein Modifications: Mechanism and Associated Disease Pathologies, in Protein Modificomics, 2019. Crossref

  3. Kersten Christian, Fleischer Edmond, Kehrein Josef, Borek Christoph, Jaenicke Elmar, Sotriffer Christoph, Brenk Ruth, How To Design Selective Ligands for Highly Conserved Binding Sites: A Case Study Using N-Myristoyltransferases as a Model System, Journal of Medicinal Chemistry, 63, 5, 2020. Crossref

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