Published 6 issues per year
ISSN Print: 1045-4403
ISSN Online: 2162-6502
Indexed in
Epithelial Mesenchymal Transition and Vascular Mimicry in Breast Cancer Stem Cells
ABSTRACT
Vasculogenic mimicry (VM), a newly defined pattern of tumor microvascularization differs from angiogenesis and vasculogenesis in its noninvolvement of endothelial cells, by which highly aggressive tumor cells can form vessel-like structures themselves, because of their high plasticity. The presence of VM has been shown to be strongly associated with a poor prognosis in several types of cancer, but biological features of tumor cells that form VM remains unknown. Human breast cancer, characterized by a group of highly heterogeneous lesions, is the most common cancer in women and one of the leading causes of cancer-related deaths worldwide. The epithelialmesenchymal transition (EMT) state in breast cancer has been associated with cancer stem cell (CSC) properties, self-renewal capabilities, resistance to conventional therapies, and a tendency for posttreatment recurrence. With increasing knowledge about cancer stem cell phenotypes and functions, they are implicated in VM formation. Studies also indicate that EMT is relevant to the acquisition and maintenance of stem cell−like characteristics and is involved in VM. This review discusses the correlation between CSCs, EMT, and VM formation with a focus on breast cancer. Also, the signalling molecules and pathways involved in VM and some recently defined direct VM targeting strategies in breast cancer are reviewed here.
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Nilendu Pritish, Kumar Ajay, Kumar Azad, Pal Jayanta K., Sharma Nilesh Kumar, Breast cancer stem cells as last soldiers eluding therapeutic burn: A hard nut to crack, International Journal of Cancer, 142, 1, 2018. Crossref
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Han Cong, Sun Baocun, Zhao Xiulan, Zhang Yanhui, Gu Qiang, Liu Fang, Zhao Nan, Wu Lili, Phosphorylation of STAT3 Promotes Vasculogenic Mimicry by Inducing Epithelial-to-Mesenchymal Transition in Colorectal Cancer, Technology in Cancer Research & Treatment, 16, 6, 2017. Crossref
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Guo Xing, Xu Shugang, Gao Xiao, Wang Jian, Xue Hao, Chen Zihang, Zhang Jinsen, Guo Xiaofan, Qian Mingyu, Qiu Wei, Li Gang, Macrophage migration inhibitory factor promotes vasculogenic mimicry formation induced by hypoxia via CXCR4/AKT/EMT pathway in human glioblastoma cells, Oncotarget, 8, 46, 2017. Crossref
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Leng Xiaoling, Huang Guofu, Zhang Lianhua, Ding Jianbing, Ma Fucheng, Lu Wan Liang, Changes in Tumor Stem Cell Markers and Epithelial-Mesenchymal Transition Markers in Nonluminal Breast Cancer after Neoadjuvant Chemotherapy and Their Correlation with Contrast-Enhanced Ultrasound, BioMed Research International, 2020, 2020. Crossref
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Leng Xiaoling, Japaer Rexida, Zhang Haijian, Yeerlan Mila, Ma Fucheng, Ding Jianbing, Relationship of shear wave elastography anisotropy with tumor stem cells and epithelial-mesenchymal transition in breast cancer, BMC Medical Imaging, 21, 1, 2021. Crossref
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Herrera-Vargas Ana K., García-Rodríguez Eduardo, Olea-Flores Monserrat, Mendoza-Catalán Miguel A., Flores-Alfaro Eugenia, Navarro-Tito Napoleón, Pro-angiogenic activity and vasculogenic mimicry in the tumor microenvironment by leptin in cancer, Cytokine & Growth Factor Reviews, 62, 2021. Crossref
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Wang Hua, Huang Bin, Li Bai Mou, Cao Kai Yuan, Mo Chen Qiang, Jiang Shuang Jian, Pan Jin Cheng, Wang Zong Ren, Lin Huan Yi, Wang Dao Hu, Qiu Shao Peng, ZEB 1‐mediated vasculogenic mimicry formation associates with epithelial–mesenchymal transition and cancer stem cell phenotypes in prostate cancer , Journal of Cellular and Molecular Medicine, 22, 8, 2018. Crossref
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Morales-Guadarrama Gabriela, Méndez-Pérez Edgar A., García-Quiroz Janice, Avila Euclides, García-Becerra Rocío, Zentella-Dehesa Alejandro, Larrea Fernando, Díaz Lorenza, Endothelium-Dependent Induction of Vasculogenic Mimicry in Human Triple-Negative Breast Cancer Cells Is Inhibited by Calcitriol and Curcumin, International Journal of Molecular Sciences, 23, 14, 2022. Crossref
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Pouliquen Daniel L., Boissard Alice, Henry Cécile, Coqueret Olivier, Guette Catherine, Curcuminoids as Modulators of EMT in Invasive Cancers: A Review of Molecular Targets With the Contribution of Malignant Mesothelioma Studies, Frontiers in Pharmacology, 13, 2022. Crossref
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Bhattacharya Susinjan, Metabolic Reprogramming and Cancer: 2022, Qeios, 2022. Crossref
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Bhattacharya Susinjan, Metabolic Reprogramming and Cancer: 2022, Qeios, 2022. Crossref