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Critical Reviews™ in Eukaryotic Gene Expression
IF: 1.734 5-Year IF: 1.848 SJR: 0.627 SNIP: 0.516 CiteScore™: 1.96

ISSN Print: 1045-4403
ISSN Online: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukaryotGeneExpr.2019026460
pages 113-121

Dysregulated Expression of Long Noncoding RNAs in Endometriosis

Xue-ying Zhang
Reproductive Medical Center, Department of Obstetrics and Gynecology, The Second Hospital of Jilin University, Changchun, Jilin, China
Lian-wen Zheng
Reproductive Medical Center, Department of Obstetrics and Gynecology, The Second Hospital of Jilin University, Changchun, Jilin, China
Chun-jin Li
College of Animal Sciences, Jilin Provincial Key Laboratory of Animal Embryo Engineering, Jilin University, Changchun, China
Ying Xu
Reproductive Medical Center, Department of Obstetrics and Gynecology, The Second Hospital of Jilin University, Changchun, Jilin, China
Xu Zhou
College of Animal Sciences, Jilin Provincial Key Laboratory of Animal Embryo Engineering, Jilin University, Changchun, China
Lu-lu Fu
Reproductive Medical Center, Department of Obstetrics and Gynecology, The Second Hospital of Jilin University, Changchun, Jilin, China
Dan-dan Li
Reproductive Medical Center, Department of Obstetrics and Gynecology, The Second Hospital of Jilin University, Changchun, Jilin, China
Li-ting Sun
College of Animal Sciences, Jilin Provincial Key Laboratory of Animal Embryo Engineering, Jilin University, Changchun, China
Di Zhang
Reproductive Medical Center, Department of Obstetrics and Gynecology, The Second Hospital of Jilin University, Changchun, Jilin, China
Man-hua Cui
Department of Obstetrics and Gynecology, The Second Hospital of Jilin University, No. 218 Ziqiang Street, Changchun, Jilin 130041, China


Endometriosis is a common debilitating gynecologic disease. Almost 10% of reproductive-age women are affected by this disease; they commonly suffer pelvic pain and/or infertility. Early diagnosis of this multifactorial disease remains difficult because its etiology is not clear and the early symptoms are nonspecific. In addition, many reproductive-age women are unwilling to undergo invasive laparoscopic surgery because of the possibility of decreasing fertility. Thus, identifying biomarkers for the early diagnosis of endometriosis a key focus of current research. Long noncoding RNAs (lncRNAs) are a class of noncoding transcripts that have length of > 200 nucleotides and lack protein-coding ability but still influence gene expression in various ways. With advances in genome-wide analysis, researchers have determined that lncRNAs play an important role in many human diseases, particularly tumors. Moreover, the role of lncRNAs in the pathogenesis of endometriosis has been continually recognized. In this review, we discuss the status of current research on dysregulated lncRNAs and their roles in the pathogenesis of endometriosis. We aim to stimulate new investigations toward the identification of lncRNAs as biomarkers for the early diagnosis and therapy of this long-term gynecological disease.


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