Published 6 issues per year
ISSN Print: 1045-4403
ISSN Online: 2162-6502
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Improving the Reprogramming Efficiency of Somatic Cells to Induced Pluripotent Stem Cells
ABSTRACT
Reprogramming shifts somatic cells toward a pluripotent state, resulting in cells that are capable of producing any tissue type, which provides a unique system for regenerative medicine. However, the poor efficiency of this process has prevented the use of induced pluripotent stem cells (iPSCs) in clinical application of stem cell biology. Importantly, more recent work has highlighted novel reprogramming factors and new strategies to enhance the reprogramming process. In this review, we focus on the transition of somatic cells to iPSCs, effective routes to improve the reprogramming efficacy, and the potential mechanism underlying this process.
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Rovina Davide, Castiglioni Elisa, Niro Francesco, Mallia Sara, Pompilio Giulio, Gowran Aoife, “Betwixt Mine Eye and Heart a League Is Took”: The Progress of Induced Pluripotent Stem-Cell-Based Models of Dystrophin-Associated Cardiomyopathy, International Journal of Molecular Sciences, 21, 19, 2020. Crossref
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Asahi Masumi G., Avaylon Jaycob, Wallsh Josh, Gallemore Ron P., Emerging biological therapies for the treatment of age-related macular degeneration, Expert Opinion on Emerging Drugs, 26, 2, 2021. Crossref
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Mackey Lantz C., Annab Lois A., Yang Jun, Rao Bhargavi, Kissling Grace E, Schurman Shepard H., Dixon Darlene, Archer Trevor K., Epigenetic Enzymes, Age, and Ancestry Regulate the Efficiency of Human iPSC Reprogramming, Stem Cells, 36, 11, 2018. Crossref