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Critical Reviews™ in Eukaryotic Gene Expression

Published 6 issues per year

ISSN Print: 1045-4403

ISSN Online: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

Indexed in

Drugs That Target Gene Expression: An Overview

Volume 6, Issue 1, 1996, pp. 75-85
DOI: 10.1615/CritRevEukarGeneExpr.v6.i1.50
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ABSTRACT

Over the last few years, it has become apparent that regulation of many normal physiological pathways, as well as the response to a wide variety of disease states, involves specific changes in gene transcription. The concept of drugs that regulate gene transcription is now firmly established. There are multiple, highly effective drugs in widespread use whose primary mechanism of action is to affect gene transcription. A major goal at Oncogene Science is to develop drugs that can modulate the normal physiological responses associated with disease by specifically increasing or decreasing the transcription of key genes. In this article, we review several examples of drugs that have been shown to act by regulating gene transcription and describe the approach Oncogene Science has pioneered.

CITED BY
  1. Gajjar Ketan, Martin-Hirsch Pierre L., Martin Francis L., CYP1B1 and hormone-induced cancer, Cancer Letters, 324, 1, 2012. Crossref

  2. Minko Tamara, Kopečková Pavla, Kopeček Jindřich, Chronic exposure to HPMA copolymer-bound adriamycin does not induce multidrug resistance in a human ovarian carcinoma cell line, Journal of Controlled Release, 59, 2, 1999. Crossref

  3. Abdul aziz Ahmad Aizat, MD Salleh MD Salzihan, Mohamad Ibtisam, Bhavaraju Venkata Murali Krishna, Yahya Maya Mazuwin, Zakaria Andee Dzulkarnaen, Gan Siew Hua, Ankathil Ravindran, Single-nucleotide polymorphisms and mRNA expression of CYP1B1 influence treatment response in triple negative breast cancer patients undergoing chemotherapy, Journal of Genetics, 97, 5, 2018. Crossref

  4. Scotto Kathleen W., Ince Tan A., Transcriptional Regulation, in Basic Science of Cancer, 2000. Crossref

  5. Biswas Subhankar, Rao C. Mallikarjuna, Epigenetics in cancer: Fundamentals and Beyond, Pharmacology & Therapeutics, 173, 2017. Crossref

Forthcoming Articles

PRMT6 promotes the immune evasion of gastric cancer via upregulating ANXA1 Liang Xu, Fenger Zhang, Binqi Yu, Shengnan Jia, Sunfu Fan PURPL promotes M2 macrophage polarization in lung cancer via regulating RBM4/xCT signaling Jipeng Guo, Chongwen Gong, Hao Wang SIAH1 promotes the pyroptosis of cardiomyocytes in diabetic cardiomyopathy via regulating IκB-α/NF-κB signaling Jinbin Wu, Yaoming Yan SLC7A2-mediated lysine catabolism inhibits immunosuppression in triple negative breast cancer Yuanyuan Sun, Yaqing Li, Chengying Jiang, Chenying Liu, Yuanming Song SIAH2-mediated degradation of ACSL4 inhibits the anti-tumor activity of CD8+ T cells in hepatocellular carcinoma Fangzheng Shu, Yuhua Shi, Xiangxiang Shan, Wenzhang Zha, Rengen Fan, Wanjiang Xue RBM15-mediated N6-methyl adenosine (m6A) modification of EZH2 drives the epithelial-mesenchymal transition of cervical cancer Ruixue Wang, Wenhua Tan Evidence-Based Storytelling and A Strategic Roadmap to Promote Cancer Prevention Via Adolescent HPV Vaccination in Northern New England Matthew Dugan, Gary Stein, Jan Carney, Sheila Clifford-Bova KDM4A-AS1 promotes cell proliferation, migration and invasion via the miR-4306/STX6 axis in hepatocellular carcinoma Wei Cao, Yuhan Ren, Ying Liu, Guoshu Cao, Zhen Chen, Fan Wang HDAC1-mediated downregulation of NEU1 exacerbates the aggressiveness of cervical cancer Nanzi Xie, Sisi Mei, Changlan Dai, Wei Chen Effect of miR-26b-5p on progression of acute myeloid leukemia by regulating USP48-mediated Wnt/β-catenin pathway Yu Xie, Lin Tan, Kun Wu, Deyun Li, Chengping Li
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