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Critical Reviews™ in Eukaryotic Gene Expression
IF: 2.156 5-Year IF: 2.255 SJR: 0.649 SNIP: 0.599 CiteScore™: 3

ISSN Print: 1045-4403
ISSN Online: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukaryotGeneExpr.2015014070
pages 1-9

Generation of Lung and Airway Epithelial Cells from Embryonic Stem Cells In Vitro

Sirous Sadeghian Chaleshtori
Department of Internal Medicine, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran; Institute of Biomedical Research, University of Tehran, Tehran, Iran
Mohammad Reza Mokhber Dezfouli
Department of Internal Medicine, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran; Institute of Biomedical Research, University of Tehran, Tehran, Iran
Mohammad Mehdi Dehghan
Institute of Biomedical Research, University of Tehran, Tehran, Iran; Department of Surgery and Radiology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
Hamid Tavanaeimanesh
Department of Internal Medicine, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran; Institute of Biomedical Research, University of Tehran, Tehran, Iran

ABSTRACT

The epithelium covers the internal surface of the lung airways and is composed of numerous cell types that arise from the anterior foregut endoderm. The ability to generate pulmonary cells from embryonic stem cells will allow study of lung development, drug screening, regenerative medicine, and modeling of lung diseases. The aim of this review is to describe the methods used to produce lung cells in vitro, based on mechanisms of lung development in during embryology.


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