Published 6 issues per year
ISSN Print: 1045-4403
ISSN Online: 2162-6502
Indexed in
miRNA in Hepatocellular Carcinoma: Pathogenesis and Therapeutic Approaches
ABSTRACT
Hepatocellular carcinoma (HCC) is a worldwide disease. Because therapeutic measures are ineffective, HCC currently has a poor prognosis. The main causes of HCCs are alcoholism, hepatitis, and metabolic syndrome. Normally hygieinic studies revealed that there is lower survival rate of HCC. MicroRNAs (miRNAs) consist of short noncoding sequences of RNA (20 to 24 nucleotides), which posttranscriptionally regulate the expression of the protein coding genes. MicroRNAs have been proposed to be prospective therapeutic molecules and targets. For testing miRNA-based therapies, HCC is a remarkable model because it may be targeted by delivery of oligonucleotides. Current studies show a beginning for analyzing the therapeutic prospects of miRNAs or anti–miRNAs. Generally, antitumor activity of miRNAs has been observed.
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Zhang Wei, Qian Sheng, Yang Guowei, Zhu Liang, Zhou Bo, Wang Jianhua, Liu Rong, Yan Zhiping, Qu Xudong, MicroRNA-199 suppresses cell proliferation, migration and invasion by downregulating RGS17 in hepatocellular carcinoma, Gene, 659, 2018. Crossref
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Hu Wen‐Yu, Wei Hai‐Yan, Liu Lu‐Yun, Li Ke‐Ming, Wang Ren‐Ben, Xu Xiao‐Qing, Feng Rui, miR ‐3607, a biomarker of hepatocellular carcinoma invasion and aggressiveness: Its relationship with epithelial‐mesenchymal transition process , IUBMB Life, 72, 8, 2020. Crossref
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Li Shu-Qun, Chen Qian, Qin Hui-Xia, Yu Ya-Qun, Weng Jun, Mo Qing-Rong, Yin Xiu-Fen, Lin Yan, Liao Wei-Jia, Long Intergenic Nonprotein Coding RNA 0152 Promotes Hepatocellular Carcinoma Progression by Regulating Phosphatidylinositol 3-Kinase/Akt/Mammalian Target of Rapamycin Signaling Pathway through miR-139/PIK3CA, The American Journal of Pathology, 190, 5, 2020. Crossref
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Ni Jun‑Sheng, Zheng Hao, Huang Zhi‑Ping, Hong Yong‑Gang, Ou Yang‑Liu, Tao Yuan‑Ping, Wang Meng‑Chao, Wang Zhen‑Guang, Yang Yuan, Zhou Wei‑Ping, MicroRNA‑197‑3p acts as a prognostic marker and inhibits cell invasion in hepatocellular carcinoma, Oncology Letters, 2018. Crossref
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Yin Liang-Chun, Xiao Gang, Zhou Rui, Huang Xiao-Ping, Li Ning-Lei, Tan Can-Liang, Xie Feng-Jiao, Weng Jun, Liu Li-Xin, Gagat Maciej, MicroRNA-361-5p Inhibits Tumorigenesis and the EMT of HCC by Targeting Twist1, BioMed Research International, 2020, 2020. Crossref
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Wu Huating, Xie Dawei, Yang Yingxia, Yang Qing, Shi Xiajun, Yang Rong, Ultrasound-Targeted Microbubble Destruction-Mediated miR-206 Overexpression Promotes Apoptosis and Inhibits Metastasis of Hepatocellular Carcinoma Cells Via Targeting PPIB, Technology in Cancer Research & Treatment, 19, 2020. Crossref
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Tian Junmei, Zhao Yongfei, Li Li, Cui Yanling, Wu Yang, MicroRNA-936 Targets JAG1 and Inhibits the Proliferation of Hepatocellular Carcinoma Cells, Technology in Cancer Research & Treatment, 20, 2021. Crossref
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Chen Can, Zong Yi, Tang Jiaojiao, Ke Ruisheng, Lv Lizhi, Wu Mengchao, Lu Junhua, miR-369-3p serves as prognostic factor and regulates cancer progression of hepatocellular carcinoma, Personalized Medicine, 18, 4, 2021. Crossref
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Li Yuqiang, Wu Bin, Sun Rongli, Zhao Mingzhou, Li Nan, miR-93-5p knockdown repressed hepatocellular carcinoma progression via increasing ERBB4 and TETs-dependent DNA demethylation, Autoimmunity, 54, 8, 2021. Crossref
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He Hui, Wang Yawei, Ye Peng, Yi Dehui, Cheng Ying, Tang Haibo, Zhu Zhi, Wang Xun, Jin Shi, Long noncoding RNA ZFPM2-AS1 acts as a miRNA sponge and promotes cell invasion through regulation of miR-139/GDF10 in hepatocellular carcinoma, Journal of Experimental & Clinical Cancer Research, 39, 1, 2020. Crossref
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Zhao LiLi, Ma Ning, Liu Gaihong, Mao Ni, Chen Fei, Li Jiao, Lidocaine Inhibits Hepatocellular Carcinoma Development by Modulating circ_ITCH/miR-421/CPEB3 Axis, Digestive Diseases and Sciences, 66, 12, 2021. Crossref
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Song Yaobo, Wang Shuang, Cheng Xiangming, LINC01006 regulates the proliferation, migration and invasion of hepatocellular carcinoma cells through regulating miR-433-3p/CBX3 axis, Annals of Hepatology, 25, 2021. Crossref
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Yin Ling, Keeler Geoffrey D., Zhang Yuanhui, Hoffman Brad E., Ling Chen, Qing Keyun, Srivastava Arun, AAV3-miRNA vectors for growth suppression of human hepatocellular carcinoma cells in vitro and human liver tumors in a murine xenograft model in vivo, Gene Therapy, 28, 7-8, 2021. Crossref
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Chen Zhangbin, Zhang Yu, Upregulation of MicroRNA-937 Predicts a Poor Prognosis and Promotes Hepatocellular Carcinoma Cell Proliferation, Migration, and Invasion, Molecular Biotechnology, 64, 1, 2022. Crossref
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Chi Yuan, Gong Zheng, Xin He, Wang Ziwen, Liu Zhaoyu, microRNA-206 prevents hepatocellular carcinoma growth and metastasis via down-regulating CREB5 and inhibiting the PI3K/AKT signaling pathway, Cell Cycle, 2022. Crossref