Library Subscription: Guest
Critical Reviews™ in Eukaryotic Gene Expression

Published 6 issues per year

ISSN Print: 1045-4403

ISSN Online: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

Indexed in

Signaling Networks that Control the Lineage Commitment and Differentiation of Bone Cells

Volume 19, Issue 1, 2009, pp. 1-46
DOI: 10.1615/CritRevEukarGeneExpr.v19.i1.10
Get accessGet access

ABSTRACT

Osteoblasts and osteoclasts are the two major bone cells involved in the bone remodeling process. Osteoblasts are responsible for bone formation while osteoclasts are the bone-resorbing cells. The major event that triggers osteogenesis and bone remodeling is the transition of mesenchymal stem cells into differentiating osteoblast cells and monocyte/macrophage precursors into differentiating osteoclasts. Imbalance in differentiation and function of these two cell types will result in skeletal diseases such as osteoporosis, Paget's disease, rheumatoid arthritis, osteopetrosis, periodontal disease, and bone cancer metastases. Osteoblast and osteoclast commitment and differentiation are controlled by complex activities involving signal transduction and transcriptional regulation of gene expression. Recent advances in molecular and genetic studies using gene targeting in mice enable a better understanding of the multiple factors and signaling networks that control the differentiation process at a molecular level. This review summarizes recent advances in studies of signaling transduction pathways and transcriptional regulation of osteoblast and osteoclast cell lineage commitment and differentiation. Understanding the signaling networks that control the commitment and differentiation of bone cells will not only expand our basic understanding of the molecular mechanisms of skeletal development but will also aid our ability to develop therapeutic means of intervention in skeletal diseases.

CITED BY
  1. Yang De-Qin, Feng Shengmei, Chen Wei, Zhao Haibo, Paulson Christie, Li Yi-Ping, V-ATPase subunit ATP6AP1 (Ac45) regulates osteoclast differentiation, extracellular acidification, lysosomal trafficking, and protease exocytosis in osteoclast-mediated bone resorption, Journal of Bone and Mineral Research, 27, 8, 2012. Crossref

  2. Yang Min, Guo Mingyang, Hu Yonghe, Jiang Yong, Scube regulates synovial angiogenesis-related signaling, Medical Hypotheses, 81, 5, 2013. Crossref

  3. Chen Zetao, Wu Chengtie, Gu Wenyi, Klein Travis, Crawford Ross, Xiao Yin, Osteogenic differentiation of bone marrow MSCs by β-tricalcium phosphate stimulating macrophages via BMP2 signalling pathway, Biomaterials, 35, 5, 2014. Crossref

  4. Cantley Melissa D., Haynes David R., Epigenetic regulation of inflammation: progressing from broad acting histone deacetylase (HDAC) inhibitors to targeting specific HDACs, Inflammopharmacology, 21, 4, 2013. Crossref

  5. Siddiqi Muhammad Hanif, Siddiqi Muhammad Zubair, Ahn Sungeun, Kang Sera, Kim Yeon-Ju, Sathishkumar Natarajan, Yang Dong-Uk, Yang Deok-Chun, Ginseng saponins and the treatment of osteoporosis: mini literature review, Journal of Ginseng Research, 37, 3, 2013. Crossref

  6. Gaur Tripti, Hussain Sadiq, Mudhasani Rajini, Parulkar Isha, Colby Jennifer L., Frederick Dana, Kream Barbara E., van Wijnen Andre J., Stein Janet L., Stein Gary S., Jones Stephen N., Lian Jane B., Dicer inactivation in osteoprogenitor cells compromises fetal survival and bone formation, while excision in differentiated osteoblasts increases bone mass in the adult mouse, Developmental Biology, 340, 1, 2010. Crossref

  7. Ma Xiaoli, Zhang Xueping, Jia Yanfei, Zu Shanshan, Han Shuyi, Xiao Dongjie, Sun Haiji, Wang Yunshan, Dexamethasone induces osteogenesis via regulation of hedgehog signalling molecules in rat mesenchymal stem cells, International Orthopaedics, 37, 7, 2013. Crossref

  8. Chen Zetao, Wu Chengtie, Yuen Jones, Klein Travis, Crawford Ross, Xiao Yin, Influence of osteocytes in thein vitroandin vivoβ-tricalcium phosphate-stimulated osteogenesis, Journal of Biomedical Materials Research Part A, 102, 8, 2014. Crossref

  9. Liu W, Liu Y, Guo T, Hu C, Luo H, Zhang L, Shi S, Cai T, Ding Y, Jin Y, TCF3, a novel positive regulator of osteogenesis, plays a crucial role in miR-17 modulating the diverse effect of canonical Wnt signaling in different microenvironments, Cell Death & Disease, 4, 3, 2013. Crossref

  10. Calleja Canelas Amparo, Varo Cenarruzabeitia Nerea, Pascual Corrales Eider, Fisiología del hueso y marcadores bioquímicos del recambio óseo, in El hueso en las enfermedades endocrinas y nutricionales, 2014. Crossref

  11. Tomlinson Ryan E., Silva Matthew J., HIF-1α regulates bone formation after osteogenic mechanical loading, Bone, 73, 2015. Crossref

  12. Wang Z, McCauley LK, Osteoclasts and odontoclasts: signaling pathways to development and disease, Oral Diseases, 17, 2, 2011. Crossref

  13. Huang Qiang, Gao Bo, Wang Long, Hu Ya-Qian, Lu Wei-Guang, Yang Liu, Luo Zhuo-Jing, Liu Jian, Protective effects of myricitrin against osteoporosis via reducing reactive oxygen species and bone-resorbing cytokines, Toxicology and Applied Pharmacology, 280, 3, 2014. Crossref

  14. Srivastava Swati, Sharma Kirti, Kumar Narender, Roy Partha, Bradykinin Regulates Osteoblast Differentiation by Akt/ERK/NFκB Signaling Axis, Journal of Cellular Physiology, 229, 12, 2014. Crossref

  15. Lambertini Elisabetta, Lisignoli Gina, Torreggiani Elena, Manferdini Cristina, Gabusi Elena, Franceschetti Tiziana, Penolazzi Letizia, Gambari Roberto, Facchini Andrea, Piva Roberta, Slug gene expression supports human osteoblast maturation, Cellular and Molecular Life Sciences, 66, 22, 2009. Crossref

  16. Léotoing Laurent, Davicco Marie-Jeanne, Lebecque Patrice, Wittrant Yohann, Coxam Véronique, The flavonoid fisetin promotes osteoblasts differentiation through Runx2 transcriptional activity, Molecular Nutrition & Food Research, 58, 6, 2014. Crossref

  17. Malhotra Deepti, Yang Yingzi, Wnts’ fashion statement: from body stature to dysplasia, BoneKEy Reports, 3, 2014. Crossref

  18. Chen Zetao, Mao Xueli, Tan Lili, Friis Thor, Wu Chengtie, Crawford Ross, Xiao Yin, Osteoimmunomodulatory properties of magnesium scaffolds coated with β-tricalcium phosphate, Biomaterials, 35, 30, 2014. Crossref

  19. Teplyuk N. M., Teplyuk V. I., Bone-specific master transcription factor Runx2 regulates signaling and metabolism related programs in osteoprogenitors, Biopolymers and Cell, 26, 4, 2010. Crossref

  20. Chen Zetao, Yi Deliang, Zheng Xuebin, Chang Jiang, Wu Chengtie, Xiao Yin, Nutrient element-based bioceramic coatings on titanium alloy stimulating osteogenesis by inducing beneficial osteoimmmunomodulation, Journal of Materials Chemistry B, 2, 36, 2014. Crossref

  21. Huang Qiang, Gao Bo, Jie Qiang, Wei Bo-Yuan, Fan Jing, Zhang Hong-Yang, Zhang Jin-Kang, Li Xiao-Jie, Shi Jun, Luo Zhuo-Jing, Yang Liu, Liu Jian, Ginsenoside-Rb2 displays anti-osteoporosis effects through reducing oxidative damage and bone-resorbing cytokines during osteogenesis, Bone, 66, 2014. Crossref

  22. Symoens Sofie, Barnes Aileen M., Gistelinck Charlotte, Malfait Fransiska, Guillemyn Brecht, Steyaert Wouter, Syx Delfien, D’hondt Sanne, Biervliet Martine, De Backer Julie, Witten Eckhard P., Leikin Sergey, Makareeva Elena, Gillessen-Kaesbach Gabriele, Huysseune Ann, Vleminckx Kris, Willaert Andy, De Paepe Anne, Marini Joan C., Coucke Paul J., Genetic Defects in TAPT1 Disrupt Ciliogenesis and Cause a Complex Lethal Osteochondrodysplasia, The American Journal of Human Genetics, 97, 4, 2015. Crossref

  23. Huang Qiang, Shi Jun, Gao Bo, Zhang Hong-Yang, Fan Jing, Li Xiao-Jie, Fan Jin-Zhu, Han Yue-Hu, Zhang Jin-Kang, Yang Liu, Luo Zhuo-Jing, Liu Jian, Gastrodin: An ancient Chinese herbal medicine as a source for anti-osteoporosis agents via reducing reactive oxygen species, Bone, 73, 2015. Crossref

  24. Uchino Kaho, Okamoto Kuniaki, Sakai Eiko, Yoneshima Erika, Iwatake Mayumi, Fukuma Yutaka, Nishishita Kazuhisa, Tsukuba Takayuki, Dual Effects of Liquiritigenin on the Proliferation of Bone Cells: Promotion of Osteoblast Differentiation and Inhibition of Osteoclast Differentiation, Phytotherapy Research, 29, 11, 2015. Crossref

  25. Cantley Melissa D, Bartold Peter M, Fairlie David P, Rainsford K D, Haynes David R, Histone deacetylase inhibitors as suppressors of bone destruction in inflammatory diseases, Journal of Pharmacy and Pharmacology, 64, 6, 2012. Crossref

  26. Patel Neel, Nizami Saqib, Song Lee, Mikami Maya, Hsu Anny, Hickernell Thomas, Chandhanayingyong Chandhanarat, Rho Shim, Compton Jocelyn T., Caldwell Jon-Michael, Kaiser Philip B., Bai Hanying, Lee Heon Goo, Fischer Charla R., Lee Francis Y., CA-074Me compound inhibits osteoclastogenesis via suppression of the NFATc1 and c-FOS signaling pathways, Journal of Orthopaedic Research, 33, 10, 2015. Crossref

  27. Napimoga Marcelo Henrique, Demasi Ana Paula Dias, Jarry Christian Rado, Ortega Mauricio Cardoso, de Araújo Vera Cavalcanti, Martinez Elizabeth Ferreira, In vitro evaluation of the biological effect of SOFAT on osteoblasts, International Immunopharmacology, 26, 2, 2015. Crossref

  28. Penolazzi Letizia, Mazzitelli Stefania, Vecchiatini Renata, Torreggiani Elena, Lambertini Elisabetta, Johnson Scott, Badylak Stephen F., Piva Roberta, Nastruzzi Claudio, Human mesenchymal stem cells seeded on extracellular matrix-scaffold: Viability and osteogenic potential, Journal of Cellular Physiology, 227, 2, 2012. Crossref

  29. Huang Qiang, Gao Bo, Wang Long, Zhang Hong-Yang, Li Xiao-Jie, Shi Jun, Wang Zheng, Zhang Jin-Kang, Yang Liu, Luo Zhuo-Jing, Liu Jian, Ophiopogonin D: A new herbal agent against osteoporosis, Bone, 74, 2015. Crossref

  30. Wattanachanya Lalita, Wang Liping, Millard Susan M., Lu Wei-Dar, O’Carroll Dylan, Hsiao Edward C., Conklin Bruce R., Nissenson Robert A., Assessing the osteoblast transcriptome in a model of enhanced bone formation due to constitutive Gs–G protein signaling in osteoblasts, Experimental Cell Research, 333, 2, 2015. Crossref

  31. Lei Qun, Chen Jiang, Huang Wenxiu, Wu Dong, Lin Hengzhang, Lai Yingzhen, Proteomic analysis of the effect of extracellular calcium ions on human mesenchymal stem cells: Implications for bone tissue engineering, Chemico-Biological Interactions, 233, 2015. Crossref

  32. Hao Cheng, Yang Shuhua, Xu Weihua, Shen Jacson K., Ye Shunan, Liu Xianzhe, Dong Zhe, Xiao Baojun, Feng Yong, MiR-708 promotes steroid-induced osteonecrosis of femoral head, suppresses osteogenic differentiation by targeting SMAD3, Scientific Reports, 6, 1, 2016. Crossref

  33. Shim Ki-Shuk, Lee Chung-Jo, Yim Nam-Hui, Gu Min Jung, Ma Jin Yeul, Alpinia officinarum Stimulates Osteoblast Mineralization and Inhibits Osteoclast Differentiation, The American Journal of Chinese Medicine, 44, 06, 2016. Crossref

  34. Mizuhashi Koji, Chaya Taro, Kanamoto Takashi, Omori Yoshihiro, Furukawa Takahisa, Malaval Luc, Obif, a Transmembrane Protein, Is Required for Bone Mineralization and Spermatogenesis in Mice, PLOS ONE, 10, 7, 2015. Crossref

  35. Rahim Muhammad Imran, Weizbauer Andreas, Evertz Florian, Hoffmann Andrea, Rohde Manfred, Glasmacher Birgit, Windhagen Henning, Gross Gerhard, Seitz Jan-Marten, Mueller Peter P., Differential magnesium implant corrosion coat formation and contribution to bone bonding, Journal of Biomedical Materials Research Part A, 105, 3, 2017. Crossref

  36. Yu Shouhe, Geng Qianqian, Pan Qiuhui, Liu Zhongyu, Ding Shan, Xiang Qi, Sun Fenyong, Wang Can, Huang Yadong, Hong An, MiR-690, a Runx2-targeted miRNA, regulates osteogenic differentiation of C2C12 myogenic progenitor cells by targeting NF-kappaB p65, Cell & Bioscience, 6, 1, 2016. Crossref

  37. Maurer Martin H., Proteomic Definitions of Mesenchymal Stem Cells, Stem Cells International, 2011, 2011. Crossref

  38. Suzuki Selly Sayuri, Garcez Aguinaldo Silva, Suzuki Hideo, Ervolino Edilson, Moon Won, Ribeiro Martha Simões, Low-level laser therapy stimulates bone metabolism and inhibits root resorption during tooth movement in a rodent model, Journal of Biophotonics, 9, 11-12, 2016. Crossref

  39. Samsa William E., Vasanji Amit, Midura Ronald J., Kondratov Roman V., Deficiency of circadian clock protein BMAL1 in mice results in a low bone mass phenotype, Bone, 84, 2016. Crossref

  40. Tang Zhurong, Tan Yanfei, Ni Yilu, Wang Jing, Zhu Xiangdong, Fan Yujiang, Chen Xuening, Yang Xiao, Zhang Xingdong, Comparison of ectopic bone formation process induced by four calcium phosphate ceramics in mice, Materials Science and Engineering: C, 70, 2017. Crossref

  41. Sittner Dana, Huhse Bettina, Steinfath Matthias, Luch Andreas, Seiler Andrea E.M., Osteogenic Differentiation of Human Embryonic Stem Cell-Derived Mesenchymal Progenitor Cells as a Model for Assessing Developmental Bone ToxicityIn Vitro, Applied In Vitro Toxicology, 2, 3, 2016. Crossref

  42. Alexander Peter G, Gottardi Riccardo, Lin Hang, Lozito Thomas P, Tuan Rocky S, Three-dimensional osteogenic and chondrogenic systems to model osteochondral physiology and degenerative joint diseases, Experimental Biology and Medicine, 239, 9, 2014. Crossref

  43. MacFarlane Elena Gallo, Haupt Julia, Dietz Harry C., Shore Eileen M., TGF-β Family Signaling in Connective Tissue and Skeletal Diseases, Cold Spring Harbor Perspectives in Biology, 9, 11, 2017. Crossref

  44. Li Kai, Shen Qingyi, Xie Youtao, You Mingyu, Huang Liping, Zheng Xuebin, Incorporation of cerium oxide into hydroxyapatite coating regulates osteogenic activity of mesenchymal stem cell and macrophage polarization, Journal of Biomaterials Applications, 31, 7, 2017. Crossref

  45. Thu Hnin Ei, Mohamed Isa Naina, Hussain Zahid, Shuid Ahmad Nazrun, Exploring molecular mechanism of bone-forming capacity of Eurycoma longifolia: Evidence of enhanced expression of bone-related biomarkers, Journal of Ayurveda and Integrative Medicine, 9, 4, 2018. Crossref

  46. Jules Joel, Li Yi-Ping, Chen Wei, C/EBPα and PU.1 exhibit different responses to RANK signaling for osteoclastogenesis, Bone, 107, 2018. Crossref

  47. Wu Xuelun, Li Shilun, Xue Peng, Li Yukun, Liraglutide, a glucagon-like peptide-1 receptor agonist, facilitates osteogenic proliferation and differentiation in MC3T3-E1 cells through phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT), extracellular signal-related kinase (ERK)1/2, and cAMP/protein kinase A (PKA) signaling pathways involving β-catenin, Experimental Cell Research, 360, 2, 2017. Crossref

  48. Galli C., Passeri G., Macaluso G.M., Osteocytes and WNT: the Mechanical Control of Bone Formation, Journal of Dental Research, 89, 4, 2010. Crossref

  49. Mada SB, Reddi S, Kumar N, Kapila S, Kapila R, Protective effects of casein-derived peptide VLPVPQK against hydrogen peroxide–induced dysfunction and cellular oxidative damage in rat osteoblastic cells, Human & Experimental Toxicology, 36, 9, 2017. Crossref

  50. Pan Houhua, Xie Youtao, Zhang Zequan, Li Kai, Hu Dandan, Zheng Xuebin, Tang Tingting, Immunomodulation effect of a hierarchical macropore/nanosurface on osteogenesis and angiogenesis, Biomedical Materials, 12, 4, 2017. Crossref

  51. Liu Jin, Lu Changwei, Wu Xiaohao, Zhang Zongkang, Li Jie, Guo Baosheng, Li Defang, Liang Chao, Dang Lei, Pan Xiaohua, Peng Songlin, Lu Aiping, Zhang Baoting, Zhang Ge, Targeting osteoblastic casein kinase-2 interacting protein-1 to enhance Smad-dependent BMP signaling and reverse bone formation reduction in glucocorticoid-induced osteoporosis, Scientific Reports, 7, 1, 2017. Crossref

  52. Torre Elisa, Molecular signaling mechanisms behind polyphenol-induced bone anabolism, Phytochemistry Reviews, 16, 6, 2017. Crossref

  53. Lu Xiang, Li Kai, Xie Youtao, Qi Shengcai, Shen Qingyi, Yu Jiangming, Huang Liping, Zheng Xuebin, Improved osteogenesis of boron incorporated calcium silicate coatings via immunomodulatory effects, Journal of Biomedical Materials Research Part A, 107, 1, 2019. Crossref

  54. Zhuo Haiya, Wang Yuhong, Zhao Qing, The Interaction between Bmal1 and Per2 in Mouse BMSC Osteogenic Differentiation, Stem Cells International, 2018, 2018. Crossref

  55. Yu Fang-yuan, Xie Cong-qin, Sun Ji-tong, Peng Wei, Huang Xun-wu, Overexpressed miR-145 inhibits osteoclastogenesis in RANKL-induced bone marrow-derived macrophages and ovariectomized mice by regulation of Smad3, Life Sciences, 202, 2018. Crossref

  56. Balogh Enikő, Paragh György, Jeney Viktória, Influence of Iron on Bone Homeostasis, Pharmaceuticals, 11, 4, 2018. Crossref

  57. Chiba Ayano, Watanabe-Takano Haruko, Terai Kenta, Fukui Hajime, Miyazaki Takahiro, Uemura Mami, Hashimoto Hisashi, Hibi Masahiko, Fukuhara Shigetomo, Mochizuki Naoki, Osteocrin, a peptide secreted from the heart and other tissues, contributes to cranial osteogenesis and chondrogenesis in zebrafish, Development, 2016. Crossref

  58. Qiu Chuan, Shen Hui, Fu Xiaoying, Xu Chao, Deng Hongwen, Meta-Analysis of Genome-Wide Association Studies Identifies Novel Functional CpG-SNPs Associated with Bone Mineral Density at Lumbar Spine, International Journal of Genomics, 2018, 2018. Crossref

  59. Letarouilly Jean-Guillaume, Broux Odile, Clabaut Aline, New insights into the epigenetics of osteoporosis, Genomics, 111, 4, 2019. Crossref

  60. Choi Jung-Yun, Han Kyu-Min, Kim Dongkyu, Lee Beom-Hee, Yoo Han-Wook, Choi Jin-Ho, Han Yong-Mahn, Impaired Osteogenesis of Disease-Specific Induced Pluripotent Stem Cells Derived from a CFC Syndrome Patient, International Journal of Molecular Sciences, 18, 12, 2017. Crossref

  61. Wang Jun, Cao Yong, Qiu Bin, Du Jianyong, Wang Tingting, Wang Chao, Deng Ran, Shi Xudong, Gao Kai, Xie Zhongwen, Yong Weidong, Ablation of protein phosphatase 5 (PP5) leads to enhanced both bone and cartilage development in mice, Cell Death & Disease, 9, 2, 2018. Crossref

  62. Pearlin , Nayak Sunita, Manivasagam Geetha, Sen Dwaipayan, Progress of Regenerative Therapy in Orthopedics, Current Osteoporosis Reports, 16, 2, 2018. Crossref

  63. Chen Zetao, Chen Lingling, Liu Runheng, Lin Yixiong, Chen Shoucheng, Lu Shifeier, Lin Zhengmei, Chen Zhuofan, Wu Chengtie, Xiao Yin, The osteoimmunomodulatory property of a barrier collagen membrane and its manipulation via coating nanometer-sized bioactive glass to improve guided bone regeneration, Biomaterials Science, 6, 5, 2018. Crossref

  64. Strecker Sara E., Unterman Shimon, Charles Lyndon F., Pivovarchick Dmitry, Maye Peter F., Edelman Elazer R., Artzi Natalie, Osterix‐mCherry Expression Allows for Early Bone Detection in a Calvarial Defect Model, Advanced Biosystems, 3, 12, 2019. Crossref

  65. Li Yi-Ping, Wu Mengrui, Chen Wei, Osteoclast Activity: Bone Resorption, Polarization, Acidification, Proton Pumps, and Chloride Channels, in Encyclopedia of Bone Biology, 2020. Crossref

  66. Li Xiang, Ning Lei, Ma Jianjun, Xie Ziang, Zhao Xiangde, Wang Gangliang, Wan Xinyu, Qiu Pengcheng, Yao Teng, Wang Haoming, Fan Shunwu, Wan Shuanglin, The PPAR-γ antagonist T007 inhibits RANKL-induced osteoclastogenesis and counteracts OVX-induced bone loss in mice, Cell Communication and Signaling, 17, 1, 2019. Crossref

  67. Pereira Rui C., Benelli Roberto, Canciani Barbara, Scaranari Monica, Daculsi Guy, Cancedda Ranieri, Gentili Chiara, Beta‐tricalcium phosphate ceramic triggers fast and robust bone formation by human mesenchymal stem cells, Journal of Tissue Engineering and Regenerative Medicine, 2019. Crossref

  68. Jakob Franz, Seefried Lothar, Kitz Christa, Stich August, Sponholz Barbara, Raab Peter, Ebert Regina, Trace Elements and Bone, in Nutritional Influences on Bone Health, 2011. Crossref

  69. Shaik Shahensha, Martin Elizabeth C., Hayes Daniel J., Gimble Jeffrey M., Devireddy Ram V., Transcriptomic Profiling of Adipose Derived Stem Cells Undergoing Osteogenesis by RNA-Seq, Scientific Reports, 9, 1, 2019. Crossref

  70. Qiu Chuan, Shen Hui, Fu Xiaoying, Xu Chao, Tian Qing, Deng Hongwen, Integrative genomic analysis predicts novel functional enhancer-SNPs for bone mineral density, Human Genetics, 138, 2, 2019. Crossref

  71. Jin Yilan, Kim Hyeung Kyoo, Lee Jeonghun, Soh Euy Young, Kim Jang-Hee, Song Insun, Chung Yoon-Sok, Choi Yong Jun, Transcription Factor HOXA9 is Linked to the Calcification and Invasion of Papillary Thyroid Carcinoma, Scientific Reports, 9, 1, 2019. Crossref

  72. Mollazadeh Samaneh, Fazly Bazzaz Bibi Sedigheh, Neshati Vajiheh, de Vries Antoine A. F., Naderi-Meshkin Hojjat, Mojarad Majid, Mirahmadi Mahdi, Neshati Zeinab, Kerachian Mohammad Amin, Overexpression of MicroRNA-148b-3p stimulates osteogenesis of human bone marrow-derived mesenchymal stem cells: the role of MicroRNA-148b-3p in osteogenesis, BMC Medical Genetics, 20, 1, 2019. Crossref

  73. Nifuji Akira, Molecular mechanisms of skeletal tissue formation, The Journal of Physical Fitness and Sports Medicine, 2, 1, 2013. Crossref

  74. Mostafavi-Pour Zohreh, Ashrafi Mohammad Reza, Talaei-Khozani Tahereh, Down regulation of ITGA4 and ITGA5 genes after formation of 3D spherules by human Wharton’s jelly stem cells (hWJSCs), Molecular Biology Reports, 45, 3, 2018. Crossref

  75. Kang Heeseog, Jha Smita, Ivovic Aleksandra, Fratzl-Zelman Nadja, Deng Zuoming, Mitra Apratim, Cabral Wayne A., Hanson Eric P., Lange Eileen, Cowen Edward W., Katz James, Roschger Paul, Klaushofer Klaus, Dale Ryan K., Siegel Richard M., Bhattacharyya Timothy, Marini Joan C., Somatic SMAD3-activating mutations cause melorheostosis by up-regulating the TGF-β/SMAD pathway, Journal of Experimental Medicine, 217, 5, 2020. Crossref

  76. Jacques Camille, Tesfaye Robel, Lavaud Melanie, Georges Steven, Baud’huin Marc, Lamoureux François, Ory Benjamin, Implication of the p53-Related miR-34c, -125b, and -203 in the Osteoblastic Differentiation and the Malignant Transformation of Bone Sarcomas, Cells, 9, 4, 2020. Crossref

  77. PARK J., WADA S., USHIDA T., AKIMOTO T., The MicroRNA-23a Has Limited Roles in Bone Formation and Homeostasis In Vivo, Physiological Research, 2015. Crossref

  78. Noh Ji-Yoon, Yang Young, Jung Haiyoung, Molecular Mechanisms and Emerging Therapeutics for Osteoporosis, International Journal of Molecular Sciences, 21, 20, 2020. Crossref

  79. Li Bo, Huang Run, Ye Jing, Liu Lei, Qin Liang, Zhou Jianhong, Zheng Yufeng, Wu Shuilin, Han Yong, A self-healing coating containing curcumin for osteoimmunomodulation to ameliorate osseointegration, Chemical Engineering Journal, 403, 2021. Crossref

  80. Al‐Bari Abdul Alim, Al Mamun Abdullah, Current advances in regulation of bone homeostasis, FASEB BioAdvances, 2, 11, 2020. Crossref

  81. Wu Hong‑Yan , Bi Rui , Sun Ting , Xie Fei , Deletion of Dicer blocks osteogenic differentiation via the inhibition of Wnt signalling, Molecular Medicine Reports, 2019. Crossref

  82. Rossi Mariana Correa, Bayerlein Daniel Leal, Brandão Jaqueline de Souza, Pfeifer João Pedro Hübbe, Rosa Gustavo dos Santos, Silva William de Melo, Martinez Luis Gallego, Saeki Margarida Juri, Alves Ana Liz Garcia, Physical and biological characterizations of TiNbSn/(Mg) system produced by powder metallurgy for use as prostheses material, Journal of the Mechanical Behavior of Biomedical Materials, 115, 2021. Crossref

  83. Arjmand Babak, Sarvari Masoumeh, Alavi-Moghadam Sepideh, Payab Moloud, Goodarzi Parisa, Gilany Kambiz, Mehrdad Neda, Larijani Bagher, Prospect of Stem Cell Therapy and Regenerative Medicine in Osteoporosis, Frontiers in Endocrinology, 11, 2020. Crossref

  84. Lee Kwan, Kim Eun, Yun Ji, Park Yong, Do Sung‑Im, Chae Seoung, Park Chan, Prognostic significance of expression of epithelial‑mesenchymal transition driver brachyury in breast cancer and its association with subtype and characteristics, Oncology Letters, 2017. Crossref

  85. Kumar Naveen, Saraber Pepijn, Ding Zhangfan, Kusumbe Anjali P., Diversity of Vascular Niches in Bones and Joints During Homeostasis, Ageing, and Diseases, Frontiers in Immunology, 12, 2021. Crossref

  86. Li Xiang, Wang Yuxin, Li Liangping, Zhou Shengji, Zhao Fengchao, Sclareol inhibits RANKL-induced osteoclastogenesis and promotes osteoblastogenesis through promoting CCN1 expression via repressing the MAPK pathway, Cell Biology and Toxicology, 37, 6, 2021. Crossref

  87. Scimeca Manuel, Giannini Elena, Antonacci Chiara, Pistolese Chiara Adriana, Spagnoli Luigi Giusto, Bonanno Elena, Microcalcifications in breast cancer: an active phenomenon mediated by epithelial cells with mesenchymal characteristics, BMC Cancer, 14, 1, 2014. Crossref

  88. Tang Jun, Xie Jing, Chen Wei, Tang Chenyi, Wu Jinjin, Wang Yiping, Zhou Xue-Dong, Zhou Hou-De, Li Yi-Ping, Runt-related transcription factor 1 is required for murine osteoblast differentiation and bone formation, Journal of Biological Chemistry, 295, 33, 2020. Crossref

  89. Qi Tang, Li Liao, Weidong Tian, The Role of Sphingolipid Metabolism in Bone Remodeling, Frontiers in Cell and Developmental Biology, 9, 2021. Crossref

  90. Al-Bari Md. Abdul Alim, Hossain Showna, Mia Ujjal, Al Mamun Md. Abdullah, Therapeutic and Mechanistic Approaches of Tridax Procumbens Flavonoids for the Treatment of Osteoporosis, Current Drug Targets, 21, 16, 2020. Crossref

  91. Marofi Faroogh, Choupani Jalal, Solali Saeed, Vahedi Ghasem, Hassanzadeh Ali, Gharibi Tohid, Hagh Majid F., ATF4, DLX3, FRA1, MSX2, C/EBP-ζ, and C/EBP-α Shape the Molecular Basis of Therapeutic Effects of Zoledronic Acid in Bone Disorders, Anti-Cancer Agents in Medicinal Chemistry, 20, 18, 2020. Crossref

  92. Salhotra Ankit, Shah Harsh N., Levi Benjamin, Longaker Michael T., Mechanisms of bone development and repair, Nature Reviews Molecular Cell Biology, 21, 11, 2020. Crossref

  93. Na Woojin, Kang Min-Kyung, Park Sin-Hye, Kim Dong Yeon, Oh Su Yeon, Oh Moon-Sik, Park Sohyun, Kang II-Jun, Kang Young-Hee, Aesculetin Accelerates Osteoblast Differentiation and Matrix-Vesicle-Mediated Mineralization, International Journal of Molecular Sciences, 22, 22, 2021. Crossref

  94. Tsartsalis Athanasios N., Lambrou George I., Vlachou Eugenia, Samartzi Athanasia, Chrousos George P., Kanaka-Gantenbein Christina, Kattamis Antonis, The Effect of Treatment and Bone Metabolic Factors on Fracture Incidence in Patients with Thalassemia-Induced Osteoporosis: An Observational Study, Current Drug Therapy, 15, 4, 2020. Crossref

  95. Tang Chen-Yi, Wu Mengrui, Zhao Dongfeng, Edwards Diep, McVicar Abigail, Luo Yuan, Zhu Guochun, Wang Yongjun, Zhou Hou-De, Chen Wei, Li Yi-Ping, LONG FANXIN, Runx1 is a central regulator of osteogenesis for bone homeostasis by orchestrating BMP and WNT signaling pathways, PLOS Genetics, 17, 1, 2021. Crossref

  96. Koosha Elham, Eames B. Frank, Two Modulators of Skeletal Development: BMPs and Proteoglycans, Journal of Developmental Biology, 10, 2, 2022. Crossref

  97. Pustylnik Sofia, Fiorino Cara, Nabavi Noushin, Zappitelli Tanya, da Silva Rosa, Aubin Jane E., Harrison Rene E., EB1 Levels Are Elevated in Ascorbic Acid (AA)-stimulated Osteoblasts and Mediate Cell-Cell Adhesion-induced Osteoblast Differentiation, Journal of Biological Chemistry, 288, 30, 2013. Crossref

  98. Zhang Bingjun, Zhang Meng, Sun Yuhua, Li Mengmeng, Han Fei, Wu Chengtie, Haversian bone-mimicking bioceramic scaffolds enhancing MSC-macrophage osteo-imunomodulation, Progress in Natural Science: Materials International, 31, 6, 2021. Crossref

  99. Mukherjee Aditi, Wilson Elizabeth M., Rotwein Peter, Selective Signaling by Akt2 Promotes Bone Morphogenetic Protein 2-Mediated Osteoblast Differentiation, Molecular and Cellular Biology, 30, 4, 2010. Crossref

  100. Hassan Mohammad Q., Gordon Jonathan A. R., Beloti Marcio M., Croce Carlo M., Wijnen Andre J. van, Stein Janet L., Stein Gary S., Lian Jane B., A network connecting Runx2, SATB2, and the miR-23a∼27a∼24-2 cluster regulates the osteoblast differentiation program, Proceedings of the National Academy of Sciences, 107, 46, 2010. Crossref

  101. Rosenberg Andrew E., The skeleton: structure, growth and development, and basis of skeletal injury, in Diagnostic Imaging of Child Abuse, 2015. Crossref

  102. Dalle Carbonare Luca, Bertacco Jessica, Gaglio Salvatore Calogero, Minoia Arianna, Cominacini Mattia, Cheri Samuele, Deiana Michela, Marchetto Giulia, Bisognin Anna, Gandini Alberto, Antoniazzi Franco, Perduca Massimiliano, Mottes Monica, Valenti Maria Teresa, Fisetin: An Integrated Approach to Identify a Strategy Promoting Osteogenesis, Frontiers in Pharmacology, 13, 2022. Crossref

  103. Fan Yi, Cui Chen, Rosen Clifford J., Sato Tadatoshi, Xu Ruoshi, Li Peiran, Wei Xi, Bi Ruiye, Yuan Quan, Zhou Chenchen, Klotho in Osx+-mesenchymal progenitors exerts pro-osteogenic and anti-inflammatory effects during mandibular alveolar bone formation and repair, Signal Transduction and Targeted Therapy, 7, 1, 2022. Crossref

  104. Rahman Md Shaifur, Akhtar Naznin, Jamil Hossen Mohammad, Banik Rajat Suvra, Asaduzzaman Sikder M, TGF-β/BMP signaling and other molecular events: regulation of osteoblastogenesis and bone formation, Bone Research, 3, 1, 2015. Crossref

  105. Grier William K., Tiffany Aleczandria S., Ramsey Matthew D., Harley Brendan A.C., Incorporating β-cyclodextrin into collagen scaffolds to sequester growth factors and modulate mesenchymal stem cell activity, Acta Biomaterialia, 76, 2018. Crossref

  106. Yadav Avinash M., Bagade Manali M., Ghumnani Soni, Raman Sujatha, Saha Bhaskar, Kubatzky Katharina F., Ashma Richa, The phytochemical plumbagin reciprocally modulates osteoblasts and osteoclasts, Biological Chemistry, 403, 2, 2022. Crossref

  107. Liu Meijing, Jin Fujun, Zhang Shuai, Li Shuang, Zhu Danqi, Cui Yi, Cai Mingxiang, Liu Xiangning, Zhang Yongbiao, Sun Yao, Liu Changhui, Wang Xiaogang, Activation of farnesoid X receptor signaling by geniposidic acid promotes osteogenesis, Phytomedicine, 103, 2022. Crossref

  108. Vrščaj Lucija Ana, Marc Janja, Ostanek Barbara, Interactome of PTH-Regulated miRNAs and Their Predicted Target Genes for Investigating the Epigenetic Effects of PTH (1–34) in Bone Metabolism, Genes, 13, 8, 2022. Crossref

  109. Lian Jane B., Stein Gary S., Montecino Martin, Stein Janet L., van Wijnen Andre J., Genetic and Epigenetic Control of the Regulatory Machinery for Skeletal Development and Bone Formation: Contributions of Vitamin D3, in Vitamin D, 2011. Crossref

  110. Li Yan, Li Lingyu, Li Xiaoyun, Luo Bingjie, Ye Qianyun, Wang Haoyu, Yang Li, Zhu Xiaofeng, Han Li, Zhang Ronghua, Tian Huaqin, Wang Panpan, A mechanistic review of chinese medicine polyphenols on bone formation and resorption, Frontiers in Pharmacology, 13, 2022. Crossref

  111. Winkler Camilla, Hasberg Christian, Jahnen-Dechent Willi, Biologische Mineralisation vs. Pathologische Kalzifizierung – die Rolle des Mineral-Chaperons Fetuin-A, Osteologie, 31, 04, 2022. Crossref

Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections Prices and Subscription Policies Begell House Contact Us Language English 中文 Русский Português German French Spain