Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
Critical Reviews™ in Eukaryotic Gene Expression
IF: 2.156 5-Year IF: 2.255 SJR: 0.649 SNIP: 0.599 CiteScore™: 3

ISSN Print: 1045-4403
ISSN Online: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukaryotGeneExpr.2020028566
pages 231-237

Association of ERCC1 and ERCC2 Gene Polymorphisms with Pancreatic Cancer Risk: A Meta-Analysis

Fuyi Xie
Clinical Laboratory, Ningbo City Medical Treatment Center, Lihuili Hospital, Ningbo, Zhejiang, 315000, China
Qi Sun
Clinical Laboratory, Ningbo City Medical Treatment Center, Lihuili Hospital, Ningbo, Zhejiang, 315000, China
En Zhang
Clinical Laboratory, Ningbo City Medical Treatment Center, Lihuili Hospital, Ningbo, Zhejiang, 315000, China
Yinyu Mu
Clinical Laboratory, Ningbo City Medical Treatment Center, Lihuili Hospital, Ningbo, Zhejiang, 315000, China

ABSTRACT

In this meta-analysis, all relative literature was retrieved through the Embase and PubMed databases. Moreover, the Stata 12.0 software package was applied to calculate the pooled odds ratio (OR) of the 95% confidence interval (CI). A total of seven studies was identified to analyze the relation between ERCC1 and ERCC2 gene polymorphisms and pancreatic cancer risk. The results showed that ERCC2 rs13181 polymorphism was associated with pancreatic cancer (CC vs. AA: OR = 1.53, 95% CI = 1.24-1.90; AC vs. AA: OR = 1.06, 95% CI = 0.92-1.22; dominant model: OR = 1.16, 95% CI = 1.02-1.32; recessive model: OR = 1.39, 95% CI = 0.13-1.70). For ERCC1 rs3212986 polymorphism, a significant correlation with pancreatic cancer risk was found (TT vs. GG: OR = 2.33, 95% CI = 1.73-3.14; GT vs. GG: OR = 1.34, 95% CI = 1.11-1.63; dominant model: OR = 1.50, 95% CI = 1.25-1.80; recessive model: OR = 1.98, 95% CI = 1.50-2.62). A lack of association was found for ERCC1 rs11615 polymorphism (TT vs. CC: OR = 1.21, 95% CI = 0.93-1.56; CT vs. CC: OR = 1.02, 95% CI = 0.87-1.21; dominant model: OR = 1.43, 95% CI = 0.80-2.50; recessive model: OR = 0.99, 95% CI = 0.65-1.51).

REFERENCES

  1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2015. CA Cancer J Clin. 2015;65:5-29.

  2. Gillen S, Schuster T, Meyer Zum Buschenfelde C, Friess H, Kleeff J. Preoperative/neoadjuvant therapy in pancreatic cancer: A systematic review and meta-analysis of response and resection percentages. PLoS Med. 2010;7:e1000267.

  3. Kim VM, Ahuja N. Early detection of pancreatic cancer. Chin J Cancer Res. 2015;27:321-31.

  4. Zheng Z, Zheng R, He Y, Sun X, Wang N, Chen T, Chen W. Risk factors for pancreatic cancer in China: A multi-center case-control study. J Epidemiol. 2016;26:64-70.

  5. Ginsberg G, Angle K, Guyton K, Sonawane B. Polymorphism in the DNA repair enzyme XRCC1: Utility of current database and implications for human health risk assessment. Mutat Res Fundam Mol Mech Mutagen. 2011;727:1-15.

  6. Wood RD, Mitchell M, Sgouros J, Lindahl T. Human DNA repair genes. Science. 2001;291:1284-9.

  7. Kiyohara C, Yoshimasu K. Genetic polymorphisms in the nucleotide excision repair pathway and lung cancer risk: A meta-analysis. Int J Med Sci. 2007;4:59-71.

  8. Wu R, Li B. A multiplicative-epistatic model for analyzing interspecific differences in outcrossing species. Biometrics. 1999;55:355-65.

  9. Lu YM, Cao LF, Li YQ, Li C. RANTES gene polymorphisms and risk of pediatric asthma: A meta-analysis. Exp Ther Med. 2012;4:918-22.

  10. Lee YH, Choi SJ, Ji JD, Song GG. Associations between the angiotensin-converting enzyme insertion/ deletion polymorphism and susceptibility to vasculitis: A meta-analysis. J Renin Angiotensin Aldosterone Syst. 2012;13:196-201.

  11. Tobias A. Assessing the influence of a single study in the meta-analysis estimate. Stata Tech Bull. 1999;8:15-7.

  12. Jiao L, Hassan MM, Bondy ML, Abbruzzese JL, Evans DB, Li D. The XPD Asp312Asn and Lys751Gln polymorphisms, corresponding haplotype, and pancreatic cancer risk. Cancer Lett. 2007;245:61-8.

  13. McWilliams RR, Bamlet WR, Cunningham JM, Goode EL, de Andrade M, Boardman LA, Petersen GM. Polymorphisms in DNA repair genes, smoking, and pancreatic adenocarcinoma risk. Cancer Res. 2008;68:4928-35.

  14. Hocevar BA, Kamendulis LM, Pu X, Perkins SM, Wang ZY, Johnston EL, DeWitt JM, Li L, Loehrer PJ, Klaunig JE, Chiorean EG. Contribution of environment and genetics to pancreatic cancer susceptibility. PLoS One. 2014;9:e90052.

  15. Zhao F, Shang Y, Zeng C, Gao D, Li K. Association of single nucleotide polymorphisms of DNA repair genes in NER pathway and susceptibility to pancreatic cancer. Int J Clin Exp Pathol. 2015;8:11579-86.

  16. Ying MF, Zhao R. Role of single nucleotide polymorphisms of DNA repair genes in susceptibility to pancreatic cancer in Chinese population. Genet Mol Res. 2016;15(1).

  17. Sileng A, Pan R, Li G, Wang W, Li J, Zhang M, Li M, Zhang Z, Lin J, Liao C. ERCC1 rs3212986 and ERCC2 rs13181 gene polymorphisms contributes to the susceptibility to pancreatic cancer in a Chinese population. Int J Clin Exp Pathol. 2016;9:5686-93.

  18. He MG, Zheng K, Tan D, Wang ZX. Association between ERCC1 and ERCC2 gene polymorphisms and susceptibility to pancreatic cancer. Genet Mol Res. 2016;15.

  19. Feng YZ, Liu YL, He XF, Wei W, Shen XL, Xie DL. Association between the XRCC1 Arg194Trp polymorphism and risk of cancer: Evidence from 201 case-control studies. Tumour Biol. 2014;35:10677-97.

  20. Li J, Li Z, Feng L, Guo W, Zhang S. Polymorphisms of DNA repair gene XRCC1 and hepatocellular carcinoma risk among East Asians: A meta-analysis. Tumour Biol. 2013;34:261-9.

  21. Dai L, Duan F, Wang P, Song C, Wang K, Zhang J. XRCC1 gene polymorphisms and lung cancer susceptibility: A metaanalysis of 44 case-control studies. Mol Biol Rep. 2012;39:9535-47.


Articles with similar content:

Association between HIF1α 1772 C/T Polymorphism and Breast Cancer Susceptibility: A Systematic Review
Critical Reviews™ in Eukaryotic Gene Expression, Vol.27, 2017, issue 4
Ting Wang
XRCC1 Arg194Trp and Arg280His Polymorphisms in Bladder Cancer Susceptibility: A Meta-Analysis
Critical Reviews™ in Eukaryotic Gene Expression, Vol.23, 2013, issue 4
Guangjun Jiao, Qinghua Yin, Lian Li, Chuan Liu, Yajie Wang, Mei Wang
Association between Methionine Synthase Reductase A66G Polymorphism and Male Infertility: A Meta-Analysis
Critical Reviews™ in Eukaryotic Gene Expression, Vol.27, 2017, issue 1
Fan Jin, Xiangli Wu, Lin Zhang, Weihai Xu
ABCB1 Polymorphisms and Childhood Acute Lymphoblastic Leukemia Risk: A Meta-Analysis
Critical Reviews™ in Eukaryotic Gene Expression, Vol.27, 2017, issue 2
Lu Zhan, Junlan Lian, Zhengyang Shao, Sunyao Wang, Haili Jin, Jiajun Ding
Association between ABCB1 G2677T/A Polymorphism and Breast Cancer Risk: A Meta-Analysis
Critical Reviews™ in Eukaryotic Gene Expression, Vol.29, 2019, issue 3
Kangke Shi, Zhihao Wei, Hongchao Liu, Yu Zhang