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Critical Reviews™ in Eukaryotic Gene Expression
IF: 2.156 5-Year IF: 2.255 SJR: 0.649 SNIP: 0.599 CiteScore™: 3

ISSN Print: 1045-4403
ISSN Online: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukaryotGeneExpr.2018025132
pages 29-36

Gene Delivery Using Lipoplexes and Polyplexes: Principles, Limitations and Solutions

Seyed Mohammad Gheibi Hayat
Department of Genetics, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Najmeh Farahani
Department of Genetics and Molecular Biology, Isfahan University of Medical Sciences, Isfahan, Iran
Esmat Safdarian
Legal Medicine Center, Legal Medicine Organization, Tehran, Iran
Amir Roointan
Department of Medical Biotechnology, School of Advanced Medical Sciences and Technologies, Shiraz, Iran; Department of Medical Biotechnology, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran
Amirhossein Sahebkar
Halal Research Center of IRI, FDA, Tehran, Iran; Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

ABSTRACT

Gene therapy has attracted considerable attention for the treatment of genetic and acquired diseases. Successful gene therapy occurs when the therapeutic genes penetrate targeted cells and become available to the intracellular active site. Currently, a promising approach in gene delivery is the use of nonviral gene delivery vectors that lack immunogenicity but have low toxicity and potential tissue specificity. The widely used, existing nonviral gene vectors are cationic lipids and polymers that can pass across extracellular and intracellular barriers. However, the toxicity of these vectors is a barrier to their use. Currently, the disadvantages of nonviral vectors have been minimized by several modifications. The main purpose of this review is to describe the pros and cons of gene delivery using cationic lipids and polymers.


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