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Critical Reviews™ in Eukaryotic Gene Expression
IF: 2.156 5-Year IF: 2.255 SJR: 0.649 SNIP: 0.599 CiteScore™: 3

ISSN Print: 1045-4403
ISSN Online: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukaryotGeneExpr.2019025150
pages 51-67

Computational Modeling of Bone Cells and Their Biomechanical Behaviors in Responses to Mechanical Stimuli

Liping Wang
Department of Hand surgery, Department of Plastic Reconstructive Surgery, Ningbo No. 6 Hospital, Ningbo, 315040, China; School of Pharmacy and Medical Sciences, and UniSA Cancer Research Institute, University of South Australia, Adelaide, SA 5001, Australia
Jianghui Dong
Department of Hand surgery, Department of Plastic Reconstructive Surgery, Ningbo No. 6 Hospital, Ningbo, 315040, China; School of Pharmacy and Medical Sciences, and UniSA Cancer Research Institute, University of South Australia, Adelaide, SA 5001, Australia
Cory J. Xian
Department of Hand surgery, Department of Plastic Reconstructive Surgery, Ningbo No. 6 Hospital, Ningbo, 315040, China; School of Pharmacy and Medical Sciences, and UniSA Cancer Research Institute, University of South Australia, Adelaide, SA 5001, Australia

ABSTRACT

Bone cells, including osteoblasts, osteoclasts, and osteocytes, have the ability to develop and maintain bone architecture. Although improved experimental testing approaches are increasing our understanding of the complex structures and functions of bone cells and bone, computational models, particularly finite element analyses, are being used to extend this knowledge and to develop a more theoretical understanding of bone cell behaviors. There are many challenges to developing an accurate and validated computational model due to the complex structure and biomechanical behaviors of the bone cells and bone tissue. A better understanding of the geometry and material properties of bone cells and bone will improve our understanding of the bone's biomechanical behaviors. In this review, we summarize and discuss the different geometric representations and material properties that have been used to model the bone cells. The current status of computational models, a comprehensive overview of the modeling methods for the bone cells, and the challenges for validating the models are presented.


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