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Critical Reviews™ in Eukaryotic Gene Expression
IF: 1.841 5-Year IF: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN Print: 1045-4403
ISSN Online: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukaryotGeneExpr.2019025931
pages 189-241

Multiple-Scales Integrative Analysis of MicroRNAs Unveils Biomarkers and Key Regulatory Connections for Hepatocellular Carcinoma

Keli Qian
Department of Infectious Disease, The Fifth People's Hospital of Chongqing, Chongqing, PR China
Qian Li
Department of Infectious Disease, The Fifth People's Hospital of Chongqing, Chongqing, PR China
Wanyan Deng
Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, PR China
Xiaohong Xiang
School of Pharmacy, Chongqing Medical and Pharmaceutical College, Chongqing 401331, China

ABSTRACT

Hepatocellular carcinoma is the sixth most common liver cancer worldwide and the third leading cause of cancer mortality. For these reasons, early diagnostic, prognostic, and therapeutic biomarkers are extremely urgent. MicroRNAs are small noncoding single-stranded RNA molecules that are reported to be involved in a variety of physiological and pathological processes during carcinogenesis. In this study, the expression characteristics, functions, and validated targets of microRNAs in HCC were summarized and potential microRNA biomarkers were confirmed from clinical specimens. Multiple-scales integrative analysis was used to predict the diagnostic, prognostic, and therapeutic potential of microRNAs in blood and tissue of HCC patients, providing novel insight into HCC diagnosis and treatment using microRNA biomarkers.


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