Published 6 issues per year
ISSN Print: 1045-4403
ISSN Online: 2162-6502
Indexed in
Molecular Signaling in Bone Regeneration
ABSTRACT
Regeneration is the ability of cells to restore lost or damaged tissues and organs in adults by pathways that mimic developmental processes. Although many of the molecular mechanisms that control cellular differentiation and growth during embryogenesis recur during fracture healing, these processes take place in a postnatal environment that is unique and distinct from those that exist during embryogenesis. Bone tissue has a remarkable capacity of regeneration without scarring. This article highlights central biological and molecular processes that are crucial in embryonic bone development. Several animal bone regeneration models are described. The patterns of gene expression during the regeneration process in the different models are reviewed. Exploring the similarities and the differences in the molecular processes in different models will contribute to the understanding of their potential in the processes of bone regeneration and tissue engineering.
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Yue Li, Durand Marianne, Lebeau Jacob M. Christian, Hogan Philippe, McManus Stephen, Roux Sophie, de Brum-Fernandes Artur J., Prostaglandin D2 induces apoptosis of human osteoclasts by activating the CRTH2 receptor and the intrinsic apoptosis pathway, Bone, 51, 3, 2012. Crossref
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Kwak Kyung-A., Kim Young-Hee, Kim Minsung, Lee Byong-Taek, Song Ho-Yeon, Bio-functionalization of polycaprolactone infiltrated BCP scaffold with silicon and fibronectin enhances osteoblast activity in vitro, Applied Surface Science, 279, 2013. Crossref
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Wang Lin, Li Chunyan, Chen Yingxin, Dong Shujun, Chen Xuesi, Zhou Yanmin, Poly(lactic-co-glycolic) Acid/Nanohydroxyapatite Scaffold Containing Chitosan Microspheres with Adrenomedullin Delivery for Modulation Activity of Osteoblasts and Vascular Endothelial Cells, BioMed Research International, 2013, 2013. Crossref
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Agenter Michael K., Harris Edward F., Blair Robert N., Influence of tooth crown size on malocclusion, American Journal of Orthodontics and Dentofacial Orthopedics, 136, 6, 2009. Crossref
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Tibullo Daniele, Di Rosa Michelino, Giallongo Cesarina, La Cava Piera, Parrinello Nunziatina L., Romano Alessandra, Conticello Concetta, Brundo Maria V., Saccone Salvatore, Malaguarnera Lucia, Di Raimondo Francesco, Bortezomib modulates CHIT1 and YKL40 in monocyte-derived osteoclast and in myeloma cells, Frontiers in Pharmacology, 6, 2015. Crossref
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GALLANT MAXIME A., CHAMOUX ESTELLE, BISSON MARTINE, WOLSEN CATARINA, PARENT JEAN-LUC, ROUX SOPHIE, de BRUM-FERNANDES ARTUR J., Increased Concentrations of Prostaglandin D2 During Post-Fracture Bone Remodeling, The Journal of Rheumatology, 37, 3, 2010. Crossref
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Tibullo Daniele, Giallongo Cesarina, La Cava Piera, Berretta Salvatore, Stagno Fabio, Chiarenza Annalisa, Conticello Concetta, Palumbo Giuseppe A., Di Raimondo Francesco, Effects of imatinib mesylate in osteoblastogenesis, Experimental Hematology, 37, 4, 2009. Crossref
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Sun Lanying, Wu Ling, Bao Chongyun, Fu Chunhua, Wang Xinlong, Yao Jinfeng, Zhang Xingdong, van Blitterswijk Clemens A., Gene expressions of Collagen type I, ALP and BMP-4 in osteo-inductive BCP implants show similar pattern to that of natural healing bones, Materials Science and Engineering: C, 29, 6, 2009. Crossref