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Critical Reviews™ in Eukaryotic Gene Expression

Published 6 issues per year

ISSN Print: 1045-4403

ISSN Online: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

Indexed in

Pleiotropic Roles of TGFβ/Smad Signaling in the Progression of Chronic Liver Disease

Volume 23, Issue 3, 2013, pp. 237-255
DOI: 10.1615/CritRevEukaryotGeneExpr.2013007490
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ABSTRACT

A wide range of pathophysiological changes are involved in the progression of chronic liver disease (CLD). The multifunctional cytokine transforming growth factor β (TGFβ) can cross talk with other signaling pathways and mediate nearly every aspect of cell physiology from growth to differentiation and cell death. TGFβ can maintain immune response homeostasis and mediate wound-healing responses. Additionally, not only can TGFβ prevent the occurrence of hepatocarcinoma by regulating the proliferation of hepatic progenitor cells, TGFβ can also play important roles in blunting inflammation by interfering with tumor inhibition response generated by inflammatory mediators. The TGFβ/Smad signaling pathway is an important response that is mediated by TGFβ. This pathway also plays multiple functions in the progression of chronic liver disease. The pleiotropic effects of TGFβ and TGFβ/Smad signaling create challenges in the treatment of CLD under conditions that might interfere with the TGFβ signaling pathway. Detailed understanding of the pleiotropic roles of TGFβ signaling in CLD might assist in the selection of more accurate therapeutic approaches, and in the targeting of the right type of cell in the development of treatment strategies, and ultimately in achieving the desired therapeutic effects.

CITED BY
  1. Wang Yan, The inhibition of microRNA-15a suppresses hepatitis B virus-associated liver cancer cell growth through the Smad/TGF-β pathway, Oncology Reports, 37, 6, 2017. Crossref

  2. Manickam Cordelia, Shah Spandan V., Lucar Olivier, Ram Daniel R., Reeves R. Keith, Cytokine-Mediated Tissue Injury in Non-human Primate Models of Viral Infections, Frontiers in Immunology, 9, 2018. Crossref

  3. Guo Xin-Xin, Yang Wen-Na, Dong Ben-Sheng, Shang Jia-Wei, Su Shi-Bing, Yan Xiu-Li, Zhang Hui, Glycyrrhetinic Acid-Induced MiR-663a Alleviates Hepatic Stellate Cell Activation by Attenuating the TGF-β/Smad Signaling Pathway, Evidence-Based Complementary and Alternative Medicine, 2020, 2020. Crossref

  4. Liu Jie, Mansouri Kamel, Judson Richard S., Martin Matthew T., Hong Huixiao, Chen Minjun, Xu Xiaowei, Thomas Russell S., Shah Imran, Predicting Hepatotoxicity Using ToxCastin VitroBioactivity and Chemical Structure, Chemical Research in Toxicology, 28, 4, 2015. Crossref

  5. Miao Youhan, Wang Meihua, Cai Xiaojuan, Zhu Qiqi, Mao Liping, Leucine rich alpha-2-glycoprotein 1 (Lrg1) silencing protects against sepsis-mediated brain injury by inhibiting transforming growth factor beta1 (TGFβ1)/SMAD signaling pathway, Bioengineered, 13, 3, 2022. Crossref

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