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Critical Reviews™ in Eukaryotic Gene Expression

Published 6 issues per year

ISSN Print: 1045-4403

ISSN Online: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

Indexed in

Functional Properties of Human Embryonic Stem Cell−Derived Cardiomyocytes

Volume 20, Issue 1, 2010, pp. 51-59
DOI: 10.1615/CritRevEukarGeneExpr.v20.i1.40
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ABSTRACT

Cardiovascular diseases are the most frequent cause of death in the industrialized world, with the main contributor being myocardial infarction. Given the high morbidity and mortality rates associated with congestive heart failure, the shortage of donor hearts for transplantation, complications resulting from immunosuppression, and long-term failure of transplanted organs, regeneration of the diseased myocardium by cell transplantation is an attractive therapeutic modality. Because of their remarkable capacity for expansion and unquestioned cardiac potential, pluripotent human embryonic stem cells (hESC) represent an attractive candidate cell source for obtaining cardiomyocytes. Moreover, a number of recent reports have shown that hESC-derived cardiomyocytes (hESC-CM) survive after transplantation into infarcted rodent hearts, form stable cardiac implants, and result in preserved contractile function. Although the latter successes give good reason for optimism, considerable challenges remain in the successful application of hESC-CM to cardiac repair. Because it is desired that the transplanted cells fully integrate within the diseased myocardium, contribute to its contractile performance, and respond appropriately to various physiological stimuli, it is of crucial importance to be familiar with their functional properties. Therefore, this review describes the characteristics of hESC-CM, including their transcriptional profile, structural and electrophysiological properties, ion channel expression, excitation-contraction coupling, and neurohumoral responsiveness.

CITED BY
  1. Blazeski Adriana, Zhu Renjun, Hunter David W., Weinberg Seth H., Boheler Kenneth R., Zambidis Elias T., Tung Leslie, Electrophysiological and contractile function of cardiomyocytes derived from human embryonic stem cells, Progress in Biophysics and Molecular Biology, 110, 2-3, 2012. Crossref

  2. Thompson Susan A., Burridge Paul W., Lipke Elizabeth A., Shamblott Michael, Zambidis Elias T., Tung Leslie, Engraftment of human embryonic stem cell derived cardiomyocytes improves conduction in an arrhythmogenic in vitro model, Journal of Molecular and Cellular Cardiology, 53, 1, 2012. Crossref

  3. Savla Jainy J., Nelson Bradley C., Perry Cynthia N., Adler Eric D., Induced Pluripotent Stem Cells for the Study of Cardiovascular Disease, Journal of the American College of Cardiology, 64, 5, 2014. Crossref

  4. Cong Shan, Cao Guifang, Liu Dongjun, Effects of different feeder layers on culture of bovine embryonic stem cell-like cells in vitro, Cytotechnology, 66, 6, 2014. Crossref

  5. Barad Lili, Schick Revital, Zeevi-Levin Naama, Itskovitz-Eldor Joseph, Binah Ofer, Human Embryonic Stem Cells vs Human Induced Pluripotent Stem Cells for Cardiac Repair, Canadian Journal of Cardiology, 30, 11, 2014. Crossref

  6. Padda Jagjit, Sequiera Glen Lester, Sareen Niketa, Dhingra Sanjiv, Stem cell therapy for cardiac regeneration: hits and misses, Canadian Journal of Physiology and Pharmacology, 93, 10, 2015. Crossref

  7. Kosmidis Georgios, Bellin Milena, Ribeiro Marcelo C., van Meer Berend, Ward-van Oostwaard Dorien, Passier Robert, Tertoolen Leon G.J., Mummery Christine L., Casini Simona, Altered calcium handling and increased contraction force in human embryonic stem cell derived cardiomyocytes following short term dexamethasone exposure, Biochemical and Biophysical Research Communications, 467, 4, 2015. Crossref

  8. Schechtman Deborah, Berti Denise Aparecida, Protein Kinase C Signaling in Embryonic Stem Cell Self Renewal and Cardiac Differentiation, in Stem Cells and Cancer Stem Cells, Volume 9, 2013. Crossref

  9. Paci Michelangelo, Sartiani Laura, Del Lungo Martina, Jaconi Marisa, Mugelli Alessandro, Cerbai Elisabetta, Severi Stefano, Mathematical modelling of the action potential of human embryonic stem cell derived cardiomyocytes, BioMedical Engineering OnLine, 11, 1, 2012. Crossref

  10. Wei Wen-Jie, Sun Hai-Ying, Ting Kai Yiu, Zhang Li-He, Lee Hon-Cheung, Li Gui-Rong, Yue Jianbo, Inhibition of Cardiomyocytes Differentiation of Mouse Embryonic Stem Cells by CD38/cADPR/Ca2+ Signaling Pathway, Journal of Biological Chemistry, 287, 42, 2012. Crossref

  11. Mercola Mark, Colas Alexandre, Willems Erik, Induced Pluripotent Stem Cells in Cardiovascular Drug Discovery, Circulation Research, 112, 3, 2013. Crossref

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