Published 6 issues per year
ISSN Print: 1045-4403
ISSN Online: 2162-6502
Indexed in
Lessons in Transcriptional Regulation Learned from Studies on Immunoglobulin Genes
ABSTRACT
In this article, we consider basic principles of eukaryotic gene transcriptional regulation which have emerged from studies on immunoglobulin heavy chain and kappa chain genes. Four areas are considered: (1) regulation by distant enhancer elements, (2) multiple regulators in a given element including particular families of regulators which were discovered by studying Ig genes, (3) achieving tissue specificity of transcription by multiple mechanisms and (4) the importance of chromatin structure for transcriptional regulation.
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CALAME KATHRYN, SEN RANJAN, Transcription of Immunoglobulin Genes, in Molecular Biology of B Cells, 2004. Crossref
-
Odegard Valerie H., Schatz David G., Targeting of somatic hypermutation, Nature Reviews Immunology, 6, 8, 2006. Crossref
-
Kang Chang-Joong, Sheridan Colleen, Koshland Marian Elliott, A Stage-Specific Enhancer of Immunoglobulin J Chain Gene Is Induced by Interleukin-2 in a Presecretor B Cell Stage, Immunity, 8, 3, 1998. Crossref
-
Salin Tuija, Timmusk Tõnis, Lendahl Urban, Metsis Madis, Structural and Functional Characterization of the Rat Neurotrophin-4 Gene, Molecular and Cellular Neuroscience, 9, 4, 1997. Crossref
-
Tran Anne H., Mrkobrada Marko, Wu Gillian E., Identification of Potential Regulatory Elements in the Human Immunoglobulin Loci, Blood Cells, Molecules, and Diseases, 29, 1, 2002. Crossref
-
Sarafova S.D., Siu G., Control of CD4 gene expression: connecting signals to outcomes in T cell development, Brazilian Journal of Medical and Biological Research, 32, 7, 1999. Crossref
-
Schweitzer Brock L., Huang Kelly J., Kamath Meghana B., Emelyanov Alexander V., Birshtein Barbara K., DeKoter Rodney P., Spi-C Has Opposing Effects to PU.1 on Gene Expression in Progenitor B Cells, The Journal of Immunology, 177, 4, 2006. Crossref
-
Henderson Andrew, Calame Kathryn, TRANSCRIPTIONAL REGULATION DURING B CELL DEVELOPMENT, Annual Review of Immunology, 16, 1, 1998. Crossref
-
Maul Raymond S., Zhang Hongxing, Reid James D., Pedigo Nancy G., Kaetzel David M., Identification of a Cell Type-specific Enhancer in the Distal 5′-Region of the Platelet-derived Growth Factor A-chain Gene, Journal of Biological Chemistry, 273, 50, 1998. Crossref
-
Tantin Dean, Oct transcription factors in development and stem cells: insights and mechanisms, Development, 140, 14, 2013. Crossref
-
Crowe Alison J., Sang Ling, Li Kelly Ke, Lee Kathleen C., Spear Brett T., Barton Michelle C., Hepatocyte Nuclear Factor 3 Relieves Chromatin-mediated Repression of the α-Fetoprotein Gene, Journal of Biological Chemistry, 274, 35, 1999. Crossref
-
Tantin Dean, Tussie-Luna Maria Isabel, Roy Ananda L., Sharp Phillip A., Regulation of Immunoglobulin Promoter Activity by TFII-I Class Transcription Factors, Journal of Biological Chemistry, 279, 7, 2004. Crossref
-
Raschke Eva E., Albert Thomas, Eick Dirk, Transcriptional Regulation of the Igκ Gene by Promoter-Proximal Pausing of RNA Polymerase II, The Journal of Immunology, 163, 8, 1999. Crossref