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Critical Reviews™ in Eukaryotic Gene Expression

Published 6 issues per year

ISSN Print: 1045-4403

ISSN Online: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

Indexed in

Lessons in Transcriptional Regulation Learned from Studies on Immunoglobulin Genes

Volume 5, Issue 3-4, 1995, pp. 255-280
DOI: 10.1615/CritRevEukarGeneExpr.v5.i3-4.30
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ABSTRACT

In this article, we consider basic principles of eukaryotic gene transcriptional regulation which have emerged from studies on immunoglobulin heavy chain and kappa chain genes. Four areas are considered: (1) regulation by distant enhancer elements, (2) multiple regulators in a given element including particular families of regulators which were discovered by studying Ig genes, (3) achieving tissue specificity of transcription by multiple mechanisms and (4) the importance of chromatin structure for transcriptional regulation.

CITED BY
  1. CALAME KATHRYN, SEN RANJAN, Transcription of Immunoglobulin Genes, in Molecular Biology of B Cells, 2004. Crossref

  2. Odegard Valerie H., Schatz David G., Targeting of somatic hypermutation, Nature Reviews Immunology, 6, 8, 2006. Crossref

  3. Kang Chang-Joong, Sheridan Colleen, Koshland Marian Elliott, A Stage-Specific Enhancer of Immunoglobulin J Chain Gene Is Induced by Interleukin-2 in a Presecretor B Cell Stage, Immunity, 8, 3, 1998. Crossref

  4. Salin Tuija, Timmusk Tõnis, Lendahl Urban, Metsis Madis, Structural and Functional Characterization of the Rat Neurotrophin-4 Gene, Molecular and Cellular Neuroscience, 9, 4, 1997. Crossref

  5. Tran Anne H., Mrkobrada Marko, Wu Gillian E., Identification of Potential Regulatory Elements in the Human Immunoglobulin Loci, Blood Cells, Molecules, and Diseases, 29, 1, 2002. Crossref

  6. Sarafova S.D., Siu G., Control of CD4 gene expression: connecting signals to outcomes in T cell development, Brazilian Journal of Medical and Biological Research, 32, 7, 1999. Crossref

  7. Schweitzer Brock L., Huang Kelly J., Kamath Meghana B., Emelyanov Alexander V., Birshtein Barbara K., DeKoter Rodney P., Spi-C Has Opposing Effects to PU.1 on Gene Expression in Progenitor B Cells, The Journal of Immunology, 177, 4, 2006. Crossref

  8. Henderson Andrew, Calame Kathryn, TRANSCRIPTIONAL REGULATION DURING B CELL DEVELOPMENT, Annual Review of Immunology, 16, 1, 1998. Crossref

  9. Maul Raymond S., Zhang Hongxing, Reid James D., Pedigo Nancy G., Kaetzel David M., Identification of a Cell Type-specific Enhancer in the Distal 5′-Region of the Platelet-derived Growth Factor A-chain Gene, Journal of Biological Chemistry, 273, 50, 1998. Crossref

  10. Tantin Dean, Oct transcription factors in development and stem cells: insights and mechanisms, Development, 140, 14, 2013. Crossref

  11. Crowe Alison J., Sang Ling, Li Kelly Ke, Lee Kathleen C., Spear Brett T., Barton Michelle C., Hepatocyte Nuclear Factor 3 Relieves Chromatin-mediated Repression of the α-Fetoprotein Gene, Journal of Biological Chemistry, 274, 35, 1999. Crossref

  12. Tantin Dean, Tussie-Luna Maria Isabel, Roy Ananda L., Sharp Phillip A., Regulation of Immunoglobulin Promoter Activity by TFII-I Class Transcription Factors, Journal of Biological Chemistry, 279, 7, 2004. Crossref

  13. Raschke Eva E., Albert Thomas, Eick Dirk, Transcriptional Regulation of the Igκ Gene by Promoter-Proximal Pausing of RNA Polymerase II, The Journal of Immunology, 163, 8, 1999. Crossref

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