Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
Critical Reviews™ in Eukaryotic Gene Expression
IF: 1.734 5-Year IF: 1.848 SJR: 0.627 SNIP: 0.516 CiteScore™: 1.96

ISSN Print: 1045-4403
ISSN Online: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v5.i3-4.30
pages 255-280

Lessons in Transcriptional Regulation Learned from Studies on Immunoglobulin Genes

Andrew J. Henderson
Department of Microbiology, Columbia University College of Physicians and Surgeons, New York
Kathryn L. Calame
Department of Microbiology, Columbia University College of Physicians and Surgeons, New York

ABSTRACT

In this article, we consider basic principles of eukaryotic gene transcriptional regulation which have emerged from studies on immunoglobulin heavy chain and kappa chain genes. Four areas are considered: (1) regulation by distant enhancer elements, (2) multiple regulators in a given element including particular families of regulators which were discovered by studying Ig genes, (3) achieving tissue specificity of transcription by multiple mechanisms and (4) the importance of chromatin structure for transcriptional regulation.


Articles with similar content:

Combined Gene Expression and DNA Occupancy Profiling as a Strategy to Identify Therapeutic Target(s) in t(8;21) Acute Myeloid Leukemia
Critical Reviews™ in Eukaryotic Gene Expression, Vol.23, 2013, issue 2
Luke F. Peterson, Miao-Chia Lo
A Compilation and Classification of DNA Binding Sites for Protein Transcription Factors from Vertebrates
Critical Reviews™ in Eukaryotic Gene Expression, Vol.4, 1994, issue 2-3
Teni Boulikas
Signals for Activation of the GM-CSF Promoter and Enhancer in T Cells
Critical Reviews™ in Immunology, Vol.17, 1997, issue 3-4
M. Frances Shannon, M. A. Vadas, P. N. Cockerill, L. S Coles
Insights on the Functional Role of Chromatin Remodelers in Osteogenic Cells
Critical Reviews™ in Eukaryotic Gene Expression, Vol.17, 2007, issue 2
Nitsan Shacham, Dafna Benayahu, Irena Shur
Interrelationships between Nuclear Structure and Ligand-Activated Intracellular Receptors
Critical Reviews™ in Eukaryotic Gene Expression, Vol.6, 1996, issue 2-3
Thomas S. Ruh, Mary F. Ruh, Robert Dunn, II