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Critical Reviews™ in Eukaryotic Gene Expression
IF: 1.841 5-Year IF: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN Print: 1045-4403
ISSN Online: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v5.i3-4.30
pages 255-280

Lessons in Transcriptional Regulation Learned from Studies on Immunoglobulin Genes

Andrew J. Henderson
Department of Microbiology, Columbia University College of Physicians and Surgeons, New York
Kathryn L. Calame
Department of Microbiology, Columbia University College of Physicians and Surgeons, New York

ABSTRACT

In this article, we consider basic principles of eukaryotic gene transcriptional regulation which have emerged from studies on immunoglobulin heavy chain and kappa chain genes. Four areas are considered: (1) regulation by distant enhancer elements, (2) multiple regulators in a given element including particular families of regulators which were discovered by studying Ig genes, (3) achieving tissue specificity of transcription by multiple mechanisms and (4) the importance of chromatin structure for transcriptional regulation.


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