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MTHFR-C677T Gene Polymorphism and Susceptibility to Acute Lymphoblastic Leukemia in Children: A Meta-Analysis

Volume 30, Issue 2, 2020, pp. 125-136
DOI: 10.1615/CritRevEukaryotGeneExpr.2020033468
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Yu Li
Department of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China
Yu-Xin Pei
Department of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China
Li-Na Wang
Department of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China
Cong Liang
Department of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China
Yan-Lai Tang
Department of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China
Xiao-Li Zhang
Department of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China
Li-Bin Huang
Department of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China
Xue-Qun Luo
Department of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China
Zhi-Yong Ke
Department of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China

ABSTRACT

Background: The association between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism (rs1801133) and childhood acute lymphoblastic leukemia (ALL) is inconsistent.
Objective: To explore the relationship between MTHFR-C677T polymorphism and susceptibility to childhood ALL.
Methods: PubMed, EMBASE, Web of Science, CNKI, Wanfang, VIP, and other databases were searched from the establishment of the database to November 2019, and all the case-control studies that met the inclusion criteria were collected. Stata 15.0 was used for meta-analysis, with calculation of the odds ratio (OR) of the relationship between MTHFR-C677T polymorphism and childhood ALL susceptibility. Ethnicity was analyzed by subgroup analysis.
Results: A total of 26 studies were included in this meta-analysis, including 4,682 children with ALL and 7144 controls. The results showed that there was no significant difference in the comparison of population of allele model, dominant gene model, recessive gene model, homozygous gene model, heterozygous gene model, and the comparison of Caucasian children. The results of the Asian child analysis suggested that the combined OR of the dominant gene model (CC + CT versus TT), homozygous model (CC versus TT) and heterozygous model (CT versus TT) was 1.32 (95% confidence interval [CI]: 1.03-1.70), 1.37 (95% CI: 1.02-1.84), and 1.27 (95% CI: 1.01-1.59), respectively, with statistically significant differences. However, there was no significant difference between the allele model and recessive gene model among Asian children.
Conclusion: The MTHFR C677T polymorphism is related to ALL in children, especially in Asian children. CC + CT, CC, and CT genotypes can increase the risk of ALL, but no association has been found in Caucasian children.

KEY WORDS: acute lymphoblastic leukaemia, MTHFR, polymorphism, meta-analysis
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CITED BY

  1. Frikha Rim, Elloumi Moez, Rebai Tarek, Kamoun Hassen, MTHFR 677T-1298C haplotype in acute lymphoblastic leukemia: Impact on methotrexate therapy, Journal of Oncology Pharmacy Practice, 2021. Crossref

  2. AlRasheed Maha M., TSH-β gene polymorphism in Saudi patients with thyroid cancer: A case-control study, Saudi Pharmaceutical Journal, 2022. Crossref

  3. 高 胜寒, Effect of MTHFR Gene Polymorphism on Methotrexate Tolerance in Children with Acute Lymphoblastic Leukemia, Advances in Clinical Medicine, 12, 11, 2022. Crossref

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