Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
Critical Reviews™ in Eukaryotic Gene Expression
IF: 2.156 5-Year IF: 2.255 SJR: 0.649 SNIP: 0.599 CiteScore™: 3

ISSN Print: 1045-4403
ISSN Online: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v22.i4.50
pages 309-324

Integrin Control of Tumor Invasion

Dara S. Missan
Center for Cell Biology & Cancer Research, Albany Medical College, Albany, New York, USA
Michael DiPersio
Center for Cell Biology & Cancer Research, Albany Medical College, Albany, New York, USA


Metastasis is the leading cause of death in cancer patients, and strategies to inhibit tumor cell invasion are a major focus of current efforts to develop cancer treatments. The extracellular matrix (ECM) provides both structural support and extracellular cues that regulate invasive tumor growth, and tumor-associated changes in ECM contribute to cancer progression. Integrins, the major receptors for cell adhesion to ECM, are important at every stage of cancer and occupy a critical position as transducers of chemical and mechanical signals that control tumor cell responses to ECM (i.e., outside-in signaling), as well as tumor-mediated changes to ECM that facilitate invasive growth and metastasis (i.e., inside-out signaling). Integrins are therefore attractive therapeutic targets for antagonistic agents. Here, we provide an overview of cancer-promoting functions of integrins on tumor cells, with a focus on roles in regulating cell invasion, ECM remodeling, tumor angiogenesis, and gene expression. We will also discuss how integrin functions are modulated by ECM ligands outside the cell, cytoskeletal/signaling proteins inside the cell, and other cell surface proteins. Finally, we will discuss current progress towards developing integrin antagonists for clinical use, including barriers that must still be overcome before integrins can be fully exploited as therapeutic targets.

Articles with similar content:

Targeting NKG2D and NKp30 Ligands Shedding to Improve NK Cell−Based Immunotherapy
Critical Reviews™ in Immunology, Vol.36, 2016, issue 6
Marco Cippitelli, Alessandra Soriani, Alessandra Zingoni, Elisabetta Vulpis, Angela Santoni, Cinzia Fionda, Ilaria Nardone
The Role of Transcription Factor YY1 in the Biology of Cancer
Critical Reviews™ in Oncogenesis, Vol.22, 2017, issue 1-2
Neeraj Agarwal, Dan Theodorescu
Targeting Integrins in Cancer
Onco Therapeutics, Vol.5, 2014, issue 3-4
Chiara Pazzagli, Sandra Donnini
Aberrant Receptor Signaling and Trafficking as Mechanisms in Oncogenesis
Critical Reviews™ in Oncogenesis, Vol.13, 2007, issue 1
Tor Erik Rusten, Kaisa Haglund, Harald Stenmark
Targeting the Regulatory Machinery of BIM for Cancer Therapy
Critical Reviews™ in Eukaryotic Gene Expression, Vol.22, 2012, issue 2
Steven Grant, Hisashi Harada