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Critical Reviews™ in Eukaryotic Gene Expression
IF: 2.156 5-Year IF: 2.255 SJR: 0.649 SNIP: 0.599 CiteScore™: 3

ISSN Print: 1045-4403
ISSN Online: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v22.i4.20
pages 281-287

Options for the Treatment of Benign Prostatic Hyperplasia

Mark Plante
Jared Wachterman
Scott Perrapato
University of Vermont


Purpose: Benign prostatic hyperplasia (BPH) is uncontrolled human prostatic epithelial and stromal cell proliferation and delayed cell death, resulting in clinical lower urinary tract symptoms (LUTS) and possibly urine retention for the majority of men as they age.
Materials and Methods: The medical literature was searched and analyzed to present the current medical and surgical therapies for men with BPH and LUTS.
Results: Active surveillance and medical therapies have advanced rapidly over the past twenty years, with the majority of men with symptomatic BPH and LUTS responding well to these therapies. Surgical therapies, once the mainstay of therapy for men with symptomatic BPH and LUTS, have become selective minimally invasive procedures designed for specific prostate gland anatomical configurations and medical refractive clinical situations.
Conclusion: Men with symptomatic BPH and LUTS today are treated successfully with active surveillance and medical and surgical therapy. Exciting new insights into the biology of benign and cancerous prostate cellular proliferation, and their response to therapy, offer new research possibilities.

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