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Critical Reviews™ in Eukaryotic Gene Expression

Published 6 issues per year

ISSN Print: 1045-4403

ISSN Online: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

Indexed in

Gap-Junctional Regulation of Osteoclast Function

Volume 13, Issue 2-4, 2003, 14 pages
DOI: 10.1615/CritRevEukaryotGeneExpr.v13.i24.70
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ABSTRACT

Previous research has shown that bone-resorbing osteoclasts contain connexin molecules that organize to hemichannel-forming connexons, which in turn form functional gap junctions in neighboring cells. So far only little is known about the role of gap junctions in osteoclasts. However, blocking of the gap-junctional communication inhibits bone resorption in vitro. Knockout mice deficient of Connexin-43, the major connexin in bone cells, show surprisingly little skeletal manifestations. Gap-junctional communication in osteoblasts and osteocytes is well documented and seems to be essential for the integrity of bone cells, as well as for the transfer of mechanical signals of bone loading. The role of gap junction in osteoclasts is unclear, so far, but some putative roles have been suggested, including their participation in osteoclast precursor fusion to multinucleated mature osteoclasts, communication in the bone multicellular unit in bone remodeling, osteoclast survival, and apoptosis.

CITED BY
  1. Schilling A. F., Filke S., Lange T., Gebauer M., Brink S., Baranowsky A., Zustin J., Amling M., Gap junctional communication in human osteoclastsin vitroandin vivo, Journal of Cellular and Molecular Medicine, 12, 6a, 2008. Crossref

  2. Said Faika, Ghoul-Mazgar Sonia, Khemiss Fathia, El Ayeb Hind, Saidane Dalila, Berdal Ariane, Ruhin-Poncet Blandine, The Effect of Etidronate on the Periodontium of Ovariectomized Rats, Journal of Periodontology, 83, 8, 2012. Crossref

  3. Baud'Huin Marc, Renault Romain, Charrier Céline, Riet Anne, Moreau Anne, Brion Régis, Gouin François, Duplomb Laurence, Heymann Dominique, Interleukin-34 is expressed by giant cell tumours of bone and plays a key role in RANKL-induced osteoclastogenesis, The Journal of Pathology, 221, 1, 2010. Crossref

  4. Batra Nidhi, Kar Rekha, Jiang Jean X., Gap junctions and hemichannels in signal transmission, function and development of bone, Biochimica et Biophysica Acta (BBA) - Biomembranes, 1818, 8, 2012. Crossref

  5. Linares Gabriel R, Brommage Robert, Powell David R, Xing Weirong, Chen Shin-Tai, Alshbool Fatima Z, Lau K-H William, Wergedal Jon E, Mohan Subburaman, Claudin 18 is a novel negative regulator of bone resorption and osteoclast differentiation, Journal of Bone and Mineral Research, 27, 7, 2012. Crossref

  6. Wenisch Sabine, Ada Cavalcanti-Adam E., Tryankowski Eva, Raabe Oksana, Kilian Olaf, Heiss Christian, Alt Volker, Arnhold Stefan, Schnettler Reinhard, Light- and transmission-electron-microscopic investigations on distribution of CD44, connexin 43 and actin cytoskeleton during the foreign body reaction to a nanoparticular hydroxyapatite in mini-pigs, Acta Biomaterialia, 8, 7, 2012. Crossref

  7. Malassiné A., Cronier L., Involvement of gap junctions in placental functions and development, Biochimica et Biophysica Acta (BBA) - Biomembranes, 1719, 1-2, 2005. Crossref

  8. Shi Ce, Zhang Honghao, Louie Ke'ale, Mishina Yuji, Sun Hongchen, BMP Signaling Mediated by BMPR1A in Osteoclasts Negatively Regulates Osteoblast Mineralization Through Suppression of Cx43, Journal of Cellular Biochemistry, 118, 3, 2017. Crossref

  9. Dayong Guo , Bonewald Lynda F., Advancing our understanding of osteocyte cell biology, Therapeutic Advances in Musculoskeletal Disease, 1, 2, 2009. Crossref

  10. Duplomb Laurence, Baud’huin Marc, Charrier Céline, Berreur Martine, Trichet Valérie, Blanchard Frédéric, Heymann Dominique, Interleukin-6 Inhibits Receptor Activator of Nuclear Factor κB Ligand-Induced Osteoclastogenesis by Diverting Cells into the Macrophage Lineage: Key Role of Serine727 Phosphorylation of Signal Transducer and Activator of Transcription 3, Endocrinology, 149, 7, 2008. Crossref

  11. Pacheco-Costa Rafael, Hassan Iraj, Reginato Rejane D., Davis Hannah M., Bruzzaniti Angela, Allen Matthew R., Plotkin Lilian I., High Bone Mass in Mice Lacking Cx37 Because of Defective Osteoclast Differentiation, Journal of Biological Chemistry, 289, 12, 2014. Crossref

  12. Duplomb Laurence, Dagouassat Maylis, Jourdon Philippe, Heymann Dominique, Concise Review: Embryonic Stem Cells: A New Tool to Study Osteoblast and Osteoclast Differentiation, Stem Cells, 25, 3, 2007. Crossref

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