Published 6 issues per year
ISSN Print: 1045-4403
ISSN Online: 2162-6502
Indexed in
Linkage of Lamins to Fidelity of Gene Transcription
ABSTRACT
Two major events are emerging as being involved in the fine regulatory mechanisms that control gene expression through the nuclear envelope/lamina. The first is the linkage of envelope proteins to transcription factors, most of which function as transcriptional repressors. The second is the interplay between nuclear lamina/nuclear envelope proteins and chromatin, through more or less direct interactions with DNA-binding proteins. The first mechanism appears to play a major role in tissue-specific functions, whereas the latter mechanism likely modifies higher-order chromatin organization, thus regulating differentiation and aging. This review highlights the importance of the study of a group of genetic diseases, collectively referred to as laminopathies, to understand the actual role played by lamins in ensuring the fidelity of gene expression and in modulating cеll differentiation.
-
Maraldi Nadir M., Lattanzi Giovanna, Cenni Vittoria, Bavelloni Alberto, Marmiroli Sandra, Manzoli Francesco A., Laminopathies and A-type lamin-associated signalling pathways, Advances in Enzyme Regulation, 50, 1, 2010. Crossref
-
Marmiroli Sandra, Bertacchini Jessika, Beretti Francesca, Cenni Vittoria, Guida Marianna, De Pol Anto, Maraldi Nadir M., Lattanzi Giovanna, A-type lamins and signaling: The PI 3-kinase/Akt pathway moves forward, Journal of Cellular Physiology, 220, 3, 2009. Crossref
-
Maraldi Nadir M., Capanni Cristina, Lattanzi Giovanna, Camozzi Daria, Facchini Andrea, Manzoli Francesco A., SREBP1 interaction with prelamin A forms: A pathogenic mechanism for lipodystrophic laminopathies, Advances in Enzyme Regulation, 48, 1, 2008. Crossref
-
Maraldi Nadir M., Lattanzi Giovanna, Laminopathies, in Cytoskeleton and Human Disease, 2012. Crossref
-
Maraldi Nadir M., A Lipid-based Code in Nuclear Signalling, in The Codes of Life, 1, 2008. Crossref
-
Boschmann Michael, Engeli Stefan, Moro Cedric, Luedtke Angelika, Adams Frauke, Gorzelniak Kerstin, Rahn Gabriele, Mähler Anja, Dobberstein Kerstin, Krüger Antje, Schmidt Saskia, Spuler Simone, Luft Friedrich C., Smith Steven R., Schmidt Hartmut H.-J., Jordan Jens, LMNA Mutations, Skeletal Muscle Lipid Metabolism, and Insulin Resistance, The Journal of Clinical Endocrinology & Metabolism, 95, 4, 2010. Crossref
-
Lattanzi Giovanna, Prelamin A-mediated nuclear envelope dynamics in normal and laminopathic cells, Biochemical Society Transactions, 39, 6, 2011. Crossref